Preoperative chemoradiation for adenocarcinoma of the pancreas

M.D. Anderson experience

D. B. Evans, J. L. Abbruzzese, J. E. Lee, S. D. Leach, C. Charnsangavej, K. R. Cleary, D. J. Buchholz, T. A. Rich

Research output: Contribution to journalArticle

Abstract

Pancreatic cancer remains the fourth leading cause of cancer-related deaths in adults in this country. Its etiology is unknown, and there is currently no effective method of early diagnosis. Although this article will focus on the proper management of patients with potentially resectable disease, such patients represent the minority of those diagnosed with pancreatic cancer. Therefore, at most medical centers, clinical and basic science research is proceeding in parallel: while attempting to optimize the length and quality of life of patients with localized pancreatic tumors, research is also focusing on developing improved strategies for early diagnosis and effective systemic therapy. For patients with localized pancreatic cancer, data from our institution support the use of detailed preoperative imaging studies to allow accurate assessment of tumor resectability. Patients found to have locally advanced or metastatic disease do not undergo laparotomy; biliary decompression, when necessary, is performed utilizing endoscopic or laparoscopic techniques. Pancreaticoduodenectomy is performed on carefully selected patients as part of a protocol-based clinical research program emphasizing the importance of multimodality management for patients with potentially resectable adenocarcinoma of the pancreatic head.

Original languageEnglish (US)
Pages (from-to)132-140
Number of pages9
JournalSeminars in Surgical Oncology
Volume11
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Pancreas
Adenocarcinoma
Pancreatic Neoplasms
Early Diagnosis
Neoplasms
Pancreaticoduodenectomy
Clinical Protocols
Decompression
Research
Laparotomy
Quality of Life

Keywords

  • chemoradiation
  • computed tomography
  • pancreatic cancer
  • pancreaticoduodenectomy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Evans, D. B., Abbruzzese, J. L., Lee, J. E., Leach, S. D., Charnsangavej, C., Cleary, K. R., ... Rich, T. A. (1995). Preoperative chemoradiation for adenocarcinoma of the pancreas: M.D. Anderson experience. Seminars in Surgical Oncology, 11(2), 132-140. https://doi.org/10.1002/ssu.2980110210

Preoperative chemoradiation for adenocarcinoma of the pancreas : M.D. Anderson experience. / Evans, D. B.; Abbruzzese, J. L.; Lee, J. E.; Leach, S. D.; Charnsangavej, C.; Cleary, K. R.; Buchholz, D. J.; Rich, T. A.

In: Seminars in Surgical Oncology, Vol. 11, No. 2, 1995, p. 132-140.

Research output: Contribution to journalArticle

Evans, DB, Abbruzzese, JL, Lee, JE, Leach, SD, Charnsangavej, C, Cleary, KR, Buchholz, DJ & Rich, TA 1995, 'Preoperative chemoradiation for adenocarcinoma of the pancreas: M.D. Anderson experience', Seminars in Surgical Oncology, vol. 11, no. 2, pp. 132-140. https://doi.org/10.1002/ssu.2980110210
Evans, D. B. ; Abbruzzese, J. L. ; Lee, J. E. ; Leach, S. D. ; Charnsangavej, C. ; Cleary, K. R. ; Buchholz, D. J. ; Rich, T. A. / Preoperative chemoradiation for adenocarcinoma of the pancreas : M.D. Anderson experience. In: Seminars in Surgical Oncology. 1995 ; Vol. 11, No. 2. pp. 132-140.
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