Preneoplastic alterations in nuclear morphology that accompany loss of tumor suppressor phenotype

Jeff Boyd, Kenneth J. Pienta, Robert H. Getzenberg, Donald S. Coffey, J. Carl Barrett

Research output: Contribution to journalArticlepeer-review

Abstract

Alterations of nuclear shape are frequently observed in tumor cells, but the genes controlling these changes and the stage in the neoplastic process at which they occur are unknown. We have studied nuclear shape changes in chemically immortalized, nontumorigenic Syrian hamster embryo cell clones that had either retained B+or lost (supB) the ability to suppress the tumorigenic phenotype when they were hybridized with a tumor cell line (BP6T). Quantitative morphometric analysis of the nuclei of cells from each of two pairs of supB+supB-variants indicated that the nuclei of supB-cells were significantly more out of round than those of their corresponding supB+clones. These data indicate that modification of nuclear structure may represent an early, preneoplastic event in multistep chemical carcinogenesis and that loss of a tumor suppressor gene function may regulate alterations in nuclear morphology. [J Nati Cancer Inst 83: 862-866, 1991]

Original languageEnglish (US)
Pages (from-to)862-866
Number of pages5
JournalJournal of the National Cancer Institute
Volume83
Issue number12
DOIs
StatePublished - Jun 19 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Preneoplastic alterations in nuclear morphology that accompany loss of tumor suppressor phenotype'. Together they form a unique fingerprint.

Cite this