Prenatal vitamin D supplementation and infant vitamin D status in Bangladesh

Nandita Perumal, Abdullah Al Mahmud, Abdullah H. Baqui, Daniel E. Roth

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To determine the effect of prenatal maternal vitamin D supplementation on infant vitamin D status in a tropical region where vitamin D supplementation is not routine. Design A prospective observational follow-up of a randomized trial. Setting Maternal-child health facility in Dhaka, Bangladesh (23°N). Subjects Infants born to pregnant women (n 160) randomized to receive 875 g (35 000 IU) cholecalciferol (vitamin D3) per week (VD) or placebo (PL) during the third trimester were followed from birth until 6 months of age (n 115). Infant serum 25-hydroxyvitamin D concentration (25(OH)D) was measured at <1, 2, 4 and 6 months of age. Results Mean infant 25(OH)D was higher in the VD v. PL group at <1 month of age (mean (sd): 80 (20) nmol/l v. 22 (18) nmol/l; P<0·001), but the difference was attenuated by 2 months (52 (19) nmol/l v. 40 (23) nmol/l; P=0·05). Groups were similar at 4 months (P=0·40) and 6 months (n 72; P=0·26). In the PL group, mean infant 25(OH)D increased to 78 (95 % CI 67, 88) nmol/l by 6 months of age (n 34). 25(OH)D was higher with infant formula-feeding and higher in summer v. winter. Conclusions Prenatal third-trimester vitamin D supplementation (875 g (35 000 IU)/week) significantly ameliorated infant vitamin D status during the neonatal period when the risk of vitamin D deficiency is greatest. Further research is warranted to determine factors that contribute to the rise in 25(OH)D during the first 6 months of life among breast-fed infants in this setting.

Original languageEnglish (US)
Pages (from-to)1865-1873
Number of pages9
JournalPublic health nutrition
Volume20
Issue number10
DOIs
StatePublished - Jul 1 2017

Keywords

  • 25-Hydroxyvitamin D
  • Bangladesh
  • Cholecalciferol
  • Developing countries
  • Infant
  • Nutrition
  • Paediatrics
  • Pregnancy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

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