Prenatal tobacco exposure predicts differential brain function during working memory in early adolescence: A preliminary investigation

David S. Bennett; Feroze B. Mohamed; Dennis P. Carmody; Muhammed Malik; Scott H. Faro; Michael Lewis

doi:10.1007/s11682-012-9192-1

Prenatal tobacco exposure predicts differential brain function during working memory in early adolescence: A preliminary investigation

David S. Bennett, Feroze B. Mohamed, Dennis P. Carmody, Muhammed Malik, Scott H. Faro, Michael Lewis

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Children prenatally exposed to tobacco exhibit higher rates of learning and emotional-behavioral problems related to worse working memory performance. Brain function, however, among tobacco exposed children while performing a working memory task has not previously been examined. This study compared the brain function of tobacco-exposed (n = 7) and unexposed (n = 11) 12-year-olds during a number N-back working memory task using an event-related functional magnetic resonance imaging (fMRI) design. Prenatal alcohol exposure, neonatal medical problems, environmental risk, and sex were statistically controlled. Tobacco-exposed children showed greater activation in inferior parietal regions, whereas unexposed children showed greater activation in inferior frontal regions. These differences were observed in the context of correct responses, suggesting that exposed and unexposed children use different brain regions and approaches to succeed in working memory tasks. Implications for future research and intervention are discussed.

Original language	English (US)
Pages (from-to)	49-59
Number of pages	11
Journal	Brain Imaging and Behavior
Volume	7
Issue number	1
DOIs	https://doi.org/10.1007/s11682-012-9192-1
State	Published - Mar 2013
Externally published	Yes

Keywords

Brain imaging
Prenatal tobacco exposure
Working memory
fMRI

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Neurology
Cognitive Neuroscience
Clinical Neurology
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Behavioral Neuroscience

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10.1007/s11682-012-9192-1

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title = "Prenatal tobacco exposure predicts differential brain function during working memory in early adolescence: A preliminary investigation",

abstract = "Children prenatally exposed to tobacco exhibit higher rates of learning and emotional-behavioral problems related to worse working memory performance. Brain function, however, among tobacco exposed children while performing a working memory task has not previously been examined. This study compared the brain function of tobacco-exposed (n = 7) and unexposed (n = 11) 12-year-olds during a number N-back working memory task using an event-related functional magnetic resonance imaging (fMRI) design. Prenatal alcohol exposure, neonatal medical problems, environmental risk, and sex were statistically controlled. Tobacco-exposed children showed greater activation in inferior parietal regions, whereas unexposed children showed greater activation in inferior frontal regions. These differences were observed in the context of correct responses, suggesting that exposed and unexposed children use different brain regions and approaches to succeed in working memory tasks. Implications for future research and intervention are discussed.",

keywords = "Brain imaging, Prenatal tobacco exposure, Working memory, fMRI",

author = "Bennett, {David S.} and Mohamed, {Feroze B.} and Carmody, {Dennis P.} and Muhammed Malik and Faro, {Scott H.} and Michael Lewis",

note = "Funding Information: This study was supported by grant #4100011451 from the Pennsylvania Department of Health (the Department specifically disclaims responsibility for any analyses, interpretations or conclusions) to the first author and by grant DA07109 from the National Institute on Drug Abuse to Michael Lewis, David Bennett and Dennis Carmody. The sponsor agencies had no involvement in the study design, collection, analysis, and interpretation of data, writing of this report, or in the decision to submit this report for publication. The authors declare that they have no conflict of interest. The authors greatly appreciate the assistance of Sara Berzenski in data collection.",

year = "2013",

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doi = "10.1007/s11682-012-9192-1",

language = "English (US)",

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AU - Bennett, David S.

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AU - Carmody, Dennis P.

AU - Malik, Muhammed

AU - Faro, Scott H.

AU - Lewis, Michael

N1 - Funding Information: This study was supported by grant #4100011451 from the Pennsylvania Department of Health (the Department specifically disclaims responsibility for any analyses, interpretations or conclusions) to the first author and by grant DA07109 from the National Institute on Drug Abuse to Michael Lewis, David Bennett and Dennis Carmody. The sponsor agencies had no involvement in the study design, collection, analysis, and interpretation of data, writing of this report, or in the decision to submit this report for publication. The authors declare that they have no conflict of interest. The authors greatly appreciate the assistance of Sara Berzenski in data collection.

PY - 2013/3

Y1 - 2013/3

N2 - Children prenatally exposed to tobacco exhibit higher rates of learning and emotional-behavioral problems related to worse working memory performance. Brain function, however, among tobacco exposed children while performing a working memory task has not previously been examined. This study compared the brain function of tobacco-exposed (n = 7) and unexposed (n = 11) 12-year-olds during a number N-back working memory task using an event-related functional magnetic resonance imaging (fMRI) design. Prenatal alcohol exposure, neonatal medical problems, environmental risk, and sex were statistically controlled. Tobacco-exposed children showed greater activation in inferior parietal regions, whereas unexposed children showed greater activation in inferior frontal regions. These differences were observed in the context of correct responses, suggesting that exposed and unexposed children use different brain regions and approaches to succeed in working memory tasks. Implications for future research and intervention are discussed.

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Prenatal tobacco exposure predicts differential brain function during working memory in early adolescence: A preliminary investigation

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