Prenatal stress attenuates ulceration in the activity stress paradigm

Kelly G. Lambert, Craig H. Kinsley, Hendree Evelyn Jones, Sabra L. Klein, Sonya N. Peretti, Kathleen M. Stewart

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


In the present study, 28 pregnant rats were subjected to either light-restraint stress or no manipulation for days 14-21 of the gestational period. At approx. 50 days of age, both male (n = 16) and female (n = 16) prenatally stressed (PS) and control offspring were subjected to the activity stress (AS) paradigm. During this subsequent stress experience, PS rats developed less ulceration than control rats. PS rats also displayed about half the activity of the control animals during the habituation phase of the AS paradigm, prior to the induction of stress. Given this decrease in baseline activity in PS animals, implications of using activity as a measure of emotionality in PS animals are discussed. Several sex differences were also observed; females differed from males in that they 1) exhibited higher activity levels in both the habituation and experimental phases of the AS procedure, 2) developed heavier relative adrenal weights, and 3) reached criteria for sacrifice in fewer days.

Original languageEnglish (US)
Pages (from-to)989-994
Number of pages6
JournalPhysiology and Behavior
Issue number5
StatePublished - May 1995
Externally publishedYes


  • Activity
  • Activity stress
  • Gastric ulceration
  • Prenatal stress
  • Prior stress experience
  • Rats
  • Sex differences

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


Dive into the research topics of 'Prenatal stress attenuates ulceration in the activity stress paradigm'. Together they form a unique fingerprint.

Cite this