Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities

Elisabeth Conradt, Tess Flannery, Judy L. Aschner, Robert D. Annett, Lisa A. Croen, Cristiane S. Duarte, Alexander M. Friedman, Constance Guille, Monique M. Hedderson, Julie A. Hofheimer, Miranda R. Jones, Christine Ladd-Acosta, Monica McGrath, Angela Moreland, Jenae M. Neiderhiser, Ruby H.N. Nguyen, Jonathan Posner, Judith L. Ross, David A. Savitz, Steven J. OndersmaBarry M. Lester

Research output: Contribution to journalReview article

Abstract

Neonatal opioid withdrawal syndrome (NOWS) has risen in prevalence from 1.2 per 1000 births in 2000 to 5.8 per 1000 births in 2012. Symptoms in neonates may include high-pitched cry, tremors, feeding difficulty, hypertonia, watery stools, and breathing problems. However, little is known about the neurodevelopmental consequences of prenatal opioid exposure in infancy, early childhood, and middle childhood. Even less is known about the cognitive, behavioral, and academic outcomes of children who develop NOWS. We review the state of the literature on the neurodevelopmental consequences of prenatal opioid exposure with a particular focus on studies in which NOWS outcomes were examined. Aiming to reduce the incidence of prenatal opioid exposure in the near future, we highlight the need for large studies with prospectively recruited participants and longitudinal designs, taking into account confounding factors such as socioeconomic status, institutional variations in care, and maternal use of other substances, to independently assess the full impact of NOWS. As a more immediate solution, we provide an agenda for future research that leverages the National Institutes of Health Environmental Influences on Child Health Outcomes program to address many of the serious methodologic gaps in the literature, and we answer key questions regarding the short- and long-term neurodevelopmental health of children with prenatal opioid exposure.

Original languageEnglish (US)
JournalPediatrics
Volume144
Issue number3
DOIs
StatePublished - Sep 1 2019

Fingerprint

Opioid Analgesics
Neonatal Abstinence Syndrome
Research
Parturition
National Institutes of Health (U.S.)
Tremor
Social Class
Respiration
Mothers
Newborn Infant
Incidence

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Conradt, E., Flannery, T., Aschner, J. L., Annett, R. D., Croen, L. A., Duarte, C. S., ... Lester, B. M. (2019). Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities. Pediatrics, 144(3). https://doi.org/10.1542/peds.2019-0128

Prenatal Opioid Exposure : Neurodevelopmental Consequences and Future Research Priorities. / Conradt, Elisabeth; Flannery, Tess; Aschner, Judy L.; Annett, Robert D.; Croen, Lisa A.; Duarte, Cristiane S.; Friedman, Alexander M.; Guille, Constance; Hedderson, Monique M.; Hofheimer, Julie A.; Jones, Miranda R.; Ladd-Acosta, Christine; McGrath, Monica; Moreland, Angela; Neiderhiser, Jenae M.; Nguyen, Ruby H.N.; Posner, Jonathan; Ross, Judith L.; Savitz, David A.; Ondersma, Steven J.; Lester, Barry M.

In: Pediatrics, Vol. 144, No. 3, 01.09.2019.

Research output: Contribution to journalReview article

Conradt, E, Flannery, T, Aschner, JL, Annett, RD, Croen, LA, Duarte, CS, Friedman, AM, Guille, C, Hedderson, MM, Hofheimer, JA, Jones, MR, Ladd-Acosta, C, McGrath, M, Moreland, A, Neiderhiser, JM, Nguyen, RHN, Posner, J, Ross, JL, Savitz, DA, Ondersma, SJ & Lester, BM 2019, 'Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities', Pediatrics, vol. 144, no. 3. https://doi.org/10.1542/peds.2019-0128
Conradt E, Flannery T, Aschner JL, Annett RD, Croen LA, Duarte CS et al. Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities. Pediatrics. 2019 Sep 1;144(3). https://doi.org/10.1542/peds.2019-0128
Conradt, Elisabeth ; Flannery, Tess ; Aschner, Judy L. ; Annett, Robert D. ; Croen, Lisa A. ; Duarte, Cristiane S. ; Friedman, Alexander M. ; Guille, Constance ; Hedderson, Monique M. ; Hofheimer, Julie A. ; Jones, Miranda R. ; Ladd-Acosta, Christine ; McGrath, Monica ; Moreland, Angela ; Neiderhiser, Jenae M. ; Nguyen, Ruby H.N. ; Posner, Jonathan ; Ross, Judith L. ; Savitz, David A. ; Ondersma, Steven J. ; Lester, Barry M. / Prenatal Opioid Exposure : Neurodevelopmental Consequences and Future Research Priorities. In: Pediatrics. 2019 ; Vol. 144, No. 3.
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