Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort

Rosalind J. Wright, Cynthia M. Visness, Agustin Calatroni, Mitchell H. Grayson, Diane R. Gold, Megan T. Sandel, Aviva Lee-Parritz, Robert A. Wood, Meyer Kattan, Gordon R. Bloomberg, Melissa Burger, Alkis Togias, Frank R. Witter, Rhoda S. Sperling, Yoel Sadovsky, James E. Gern

Research output: Contribution to journalArticle

Abstract

Rationale: Stress-elicited disruption of immunity begins in utero. Objectives: Associations among prenatal maternal stress and cord blood mononuclear cell (CBMC) cytokine responses were prospectively examined in the Urban Environment and Childhood Asthma Study (n = 557 families). Methods: Prenatal maternal stress included financial hardship, difficult life circumstances, community violence, and neighborhood/block and housing conditions. Factor analysis produced latent variables representing three contexts: individual stressors and ecological-level strains (housing problems and neighborhood problems), which were combined to create a composite cumulative stress indicator. CBMCs were incubated with innate (lipopolysaccharide, polyinosinic-polycytidylic acid, cytosine-phosphate-guanine dinucleotides, peptidoglycan) and adaptive (tetanus, dustmite, cockroach) stimuli, respiratory syncytial virus, phytohemagglutinin, or medium alone. Cytokines were measured using multiplex ELISAs. Using linear regression, associations among increasing cumulative stress and cytokine responses were examined, adjusting for sociodemographic factors, parity, season of birth, maternal asthma and steroid use, and potential pathway variables (prenatal smoking, birth weight for gestational age). Measurements and Main Results: Mothers were primarily minorities (Black [71%], Latino [19%]) with an income less than $15,000 (69%). Mothers with the highest cumulative stress were older and more likely to have asthma and deliver lower birth weight infants. Higher prenatal stress was related to increased IL-8 production after microbial (CpG, PIC, peptidoglycan) stimuli and increased tumor necrosis factor-α to microbial stimuli (CpG, PIC). In the adaptive panel, higher stress was associated with increased IL-13 after dust mite stimulation and reduced phytohemagglutinin-induced IFN-γ. Conclusions: Prenatal stress was associated with altered innate and adaptive immune responses in CBMCs. Stress-induced perinatal immunomodulation may impact the expression of allergic disease in these children.

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalAmerican journal of respiratory and critical care medicine
Volume182
Issue number1
DOIs
StatePublished - Jul 1 2010

Keywords

  • Adaptive
  • Cord blood
  • Cytokines
  • Innate
  • Psychological stress

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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    Wright, R. J., Visness, C. M., Calatroni, A., Grayson, M. H., Gold, D. R., Sandel, M. T., Lee-Parritz, A., Wood, R. A., Kattan, M., Bloomberg, G. R., Burger, M., Togias, A., Witter, F. R., Sperling, R. S., Sadovsky, Y., & Gern, J. E. (2010). Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort. American journal of respiratory and critical care medicine, 182(1), 25-33. https://doi.org/10.1164/rccm.200904-0637OC