Prenatal diagnosis has been performed in more than 11,000 fetuses at risk for hematologic diseases. This paper summarizes the data from 30 centers from 1975 to 1985: 70% had fetal blood taken for hemoglobinopathies, of which 93% were for thalassemia and 7% for sickle disorders; 13% had DNA analyses for hemoglobinopathies, 54% for thalassemia and 46% for sickle disorders; 17% were investigated for other hematologic diseases using fetal blood, while 0.1% of the cases were studied for other diseases by DNA techniques. Error rates for all types of studies were under 1%, and fetal losses below 4%. Approximately 95% of families received safe, accurate information.
|Original language||English (US)|
|Number of pages||5|
|State||Published - 1987|
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