Prenatal diagnosis of hematologic diseases, 1986 update

B. P. Alter

Research output: Contribution to journalArticlepeer-review


Prenatal diagnosis has been performed in more than 11,000 fetuses at risk for hematologic diseases. This paper summarizes the data from 30 centers from 1975 to 1985: 70% had fetal blood taken for hemoglobinopathies, of which 93% were for thalassemia and 7% for sickle disorders; 13% had DNA analyses for hemoglobinopathies, 54% for thalassemia and 46% for sickle disorders; 17% were investigated for other hematologic diseases using fetal blood, while 0.1% of the cases were studied for other diseases by DNA techniques. Error rates for all types of studies were under 1%, and fetal losses below 4%. Approximately 95% of families received safe, accurate information.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalActa Haematologica
Issue number2-3
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Hematology


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