PRENATAL DIAGNOSIS OF HAEMOPHILIA A BY FACTOR VIII GENE ANALYSIS

StylianosE Antonarakis, KarenL Copeland, RobertJ Carpenter, CarlA Carta, LeonW Hoyer, C. Thomas Caskey, JohnJ Toole, Haig Kazazian

Research output: Contribution to journalArticle

Abstract

Cloned factor VIII deoxyribose nucleic acid (DNA) sequences were used as probes in the prenatal diagnosis of haemophilia A. Fetal DNA from cultured amniotic fluid cells was examined for a DNA polymorphism within the factor VIII gene which marked the haemophilia A gene in the pregnant obligate carrier. The fetus was predicted to be an affected male, and the diagnosis of haemophilia A was confirmed both in utero and after termination of the pregnancy.

Original languageEnglish (US)
Pages (from-to)1407-1409
Number of pages3
JournalThe Lancet
Volume325
Issue number8443
DOIs
Publication statusPublished - Jun 22 1985

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Antonarakis, S., Copeland, K., Carpenter, R., Carta, C., Hoyer, L., Caskey, C. T., ... Kazazian, H. (1985). PRENATAL DIAGNOSIS OF HAEMOPHILIA A BY FACTOR VIII GENE ANALYSIS. The Lancet, 325(8443), 1407-1409. https://doi.org/10.1016/S0140-6736(85)91842-2