PRENATAL DIAGNOSIS OF HAEMOPHILIA A BY FACTOR VIII GENE ANALYSIS

Stylianos E. Antonarakis, Karen L. Copeland, Robert J. Carpenter, Carl A. Carta, Leon W. Hoyer, C. Thomas Caskey, John J. Toole, Haig H. Kazazian

Research output: Contribution to journalArticlepeer-review

Abstract

Cloned factor VIII deoxyribose nucleic acid (DNA) sequences were used as probes in the prenatal diagnosis of haemophilia A. Fetal DNA from cultured amniotic fluid cells was examined for a DNA polymorphism within the factor VIII gene which marked the haemophilia A gene in the pregnant obligate carrier. The fetus was predicted to be an affected male, and the diagnosis of haemophilia A was confirmed both in utero and after termination of the pregnancy.

Original languageEnglish (US)
Pages (from-to)1407-1409
Number of pages3
JournalThe Lancet
Volume325
Issue number8443
DOIs
StatePublished - Jun 22 1985

ASJC Scopus subject areas

  • Medicine(all)

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