PRENATAL DIAGNOSIS OF HAEMOPHILIA A BY FACTOR VIII GENE ANALYSIS

StylianosE Antonarakis, KarenL Copeland, RobertJ Carpenter, CarlA Carta, LeonW Hoyer, C. Thomas Caskey, JohnJ Toole, Haig Kazazian

Research output: Contribution to journalArticle

Abstract

Cloned factor VIII deoxyribose nucleic acid (DNA) sequences were used as probes in the prenatal diagnosis of haemophilia A. Fetal DNA from cultured amniotic fluid cells was examined for a DNA polymorphism within the factor VIII gene which marked the haemophilia A gene in the pregnant obligate carrier. The fetus was predicted to be an affected male, and the diagnosis of haemophilia A was confirmed both in utero and after termination of the pregnancy.

Original languageEnglish (US)
Pages (from-to)1407-1409
Number of pages3
JournalThe Lancet
Volume325
Issue number8443
DOIs
StatePublished - Jun 22 1985

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Deoxyribose
Factor VIII
Hemophilia A
Prenatal Diagnosis
Nucleic Acids
Genes
Amniotic Fluid
Fetus
Pregnancy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Antonarakis, S., Copeland, K., Carpenter, R., Carta, C., Hoyer, L., Caskey, C. T., ... Kazazian, H. (1985). PRENATAL DIAGNOSIS OF HAEMOPHILIA A BY FACTOR VIII GENE ANALYSIS. The Lancet, 325(8443), 1407-1409. https://doi.org/10.1016/S0140-6736(85)91842-2

PRENATAL DIAGNOSIS OF HAEMOPHILIA A BY FACTOR VIII GENE ANALYSIS. / Antonarakis, StylianosE; Copeland, KarenL; Carpenter, RobertJ; Carta, CarlA; Hoyer, LeonW; Caskey, C. Thomas; Toole, JohnJ; Kazazian, Haig.

In: The Lancet, Vol. 325, No. 8443, 22.06.1985, p. 1407-1409.

Research output: Contribution to journalArticle

Antonarakis, S, Copeland, K, Carpenter, R, Carta, C, Hoyer, L, Caskey, CT, Toole, J & Kazazian, H 1985, 'PRENATAL DIAGNOSIS OF HAEMOPHILIA A BY FACTOR VIII GENE ANALYSIS', The Lancet, vol. 325, no. 8443, pp. 1407-1409. https://doi.org/10.1016/S0140-6736(85)91842-2
Antonarakis S, Copeland K, Carpenter R, Carta C, Hoyer L, Caskey CT et al. PRENATAL DIAGNOSIS OF HAEMOPHILIA A BY FACTOR VIII GENE ANALYSIS. The Lancet. 1985 Jun 22;325(8443):1407-1409. https://doi.org/10.1016/S0140-6736(85)91842-2
Antonarakis, StylianosE ; Copeland, KarenL ; Carpenter, RobertJ ; Carta, CarlA ; Hoyer, LeonW ; Caskey, C. Thomas ; Toole, JohnJ ; Kazazian, Haig. / PRENATAL DIAGNOSIS OF HAEMOPHILIA A BY FACTOR VIII GENE ANALYSIS. In: The Lancet. 1985 ; Vol. 325, No. 8443. pp. 1407-1409.
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