Prenatal Cerebellar Disruptions: Neuroimaging Spectrum of Findings in Correlation with Likely Mechanisms and Etiologies of Injury

Andrea Poretti, Eugen Boltshauser, Thierry A G M Huisman

Research output: Contribution to journalReview article

Abstract

There is increasing evidence that the cerebellum is susceptible to prenatal infections and hemorrhages and that congenital morphologic anomalies of the cerebellum may be caused by disruptive (acquired) causes. Starting from the neuroimaging pattern, this report describes a spectrum of prenatal cerebellar disruptions including cerebellar agenesis, unilateral cerebellar hypoplasia, cerebellar cleft, global cerebellar hypoplasia, and vanishing cerebellum in Chiari type II malformation. The neuroimaging findings, possible causative disruptive events, and clinical features of each disruption are discussed. Recognition of cerebellar disruptions and their differentiation from cerebellar malformations is important in terms of diagnosis, prognosis, and genetic counselling.

Original languageEnglish (US)
Pages (from-to)359-372
Number of pages14
JournalNeuroimaging Clinics of North America
Volume26
Issue number3
DOIs
StatePublished - Aug 1 2016

Keywords

  • Cerebellar agenesis
  • Cerebellar disruption
  • Cerebellar hypoplasia
  • Hemorrhage
  • Neuroimaging
  • Prenatal
  • Unilateral cerebellar hypoplasia
  • Vanishing cerebellum

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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