TY - JOUR
T1 - Prenatal Cerebellar Disruptions
T2 - Neuroimaging Spectrum of Findings in Correlation with Likely Mechanisms and Etiologies of Injury
AU - Poretti, Andrea
AU - Boltshauser, Eugen
AU - Huisman, Thierry A.G.M.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - There is increasing evidence that the cerebellum is susceptible to prenatal infections and hemorrhages and that congenital morphologic anomalies of the cerebellum may be caused by disruptive (acquired) causes. Starting from the neuroimaging pattern, this report describes a spectrum of prenatal cerebellar disruptions including cerebellar agenesis, unilateral cerebellar hypoplasia, cerebellar cleft, global cerebellar hypoplasia, and vanishing cerebellum in Chiari type II malformation. The neuroimaging findings, possible causative disruptive events, and clinical features of each disruption are discussed. Recognition of cerebellar disruptions and their differentiation from cerebellar malformations is important in terms of diagnosis, prognosis, and genetic counselling.
AB - There is increasing evidence that the cerebellum is susceptible to prenatal infections and hemorrhages and that congenital morphologic anomalies of the cerebellum may be caused by disruptive (acquired) causes. Starting from the neuroimaging pattern, this report describes a spectrum of prenatal cerebellar disruptions including cerebellar agenesis, unilateral cerebellar hypoplasia, cerebellar cleft, global cerebellar hypoplasia, and vanishing cerebellum in Chiari type II malformation. The neuroimaging findings, possible causative disruptive events, and clinical features of each disruption are discussed. Recognition of cerebellar disruptions and their differentiation from cerebellar malformations is important in terms of diagnosis, prognosis, and genetic counselling.
KW - Cerebellar agenesis
KW - Cerebellar disruption
KW - Cerebellar hypoplasia
KW - Hemorrhage
KW - Neuroimaging
KW - Prenatal
KW - Unilateral cerebellar hypoplasia
KW - Vanishing cerebellum
UR - http://www.scopus.com/inward/record.url?scp=84991234387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991234387&partnerID=8YFLogxK
U2 - 10.1016/j.nic.2016.03.006
DO - 10.1016/j.nic.2016.03.006
M3 - Review article
C2 - 27423799
AN - SCOPUS:84991234387
VL - 26
SP - 359
EP - 372
JO - Neuroimaging Clinics of North America
JF - Neuroimaging Clinics of North America
SN - 1052-5149
IS - 3
ER -