TY - JOUR
T1 - Prenatal and postnatal insults differentially contribute to executive function and cognition
T2 - Utilizing touchscreen technology for perinatal brain injury research
AU - Muthukumar, Sankar
AU - Mehrotra, Karnika
AU - Fouda, Mohammed
AU - Hamimi, Sarah
AU - Jantzie, Lauren L.
AU - Robinson, Shenandoah
N1 - Publisher Copyright:
© 2022
PY - 2022/8
Y1 - 2022/8
N2 - The use of touchscreen technology to evaluate cognitive deficits in animal models has grown tremendously over the past 20 years. The touchscreen apparatus encompasses many advantages, namely a high level of standardization and translational capability. Improvements in technology in recent years have expanded the versatility of the touchscreen platform, as it is able to test distinct cognitive modalities including working memory, attention, discrimination, and association. Importantly, touchscreen technology has allowed researchers to explore deficits in multiple pillars of cognition in a wide variety of perinatal disorders with neurological sequelae across critical developmental windows. The touchscreen platform has been used to dissect deficits in antenatal CNS injury including fetal alcohol syndrome, prenatal opioid exposure, and chorioamnionitis, to peripartum insults such as term hypoxic-ischemic encephalopathy, to early postnatal insults including infantile traumatic brain injury. Most importantly, touchscreen technology offers the sensitivity necessary to detect subtle injury and treatment-induced changes in cognition and executive function beyond those offered by more rudimentary tests of rodent cognition. Understanding the pathophysiology of these disorders in rodents is paramount to addressing these deficits in human infants and dissecting the neural circuitry essential to perinatal brain injury pathophysiology and responsiveness to novel therapeutics. Touchscreen testing provides an effective, facile, sophisticated technique to accelerate the goal of improving cognitive and behavioral outcomes of children who suffer perinatal brain injury.
AB - The use of touchscreen technology to evaluate cognitive deficits in animal models has grown tremendously over the past 20 years. The touchscreen apparatus encompasses many advantages, namely a high level of standardization and translational capability. Improvements in technology in recent years have expanded the versatility of the touchscreen platform, as it is able to test distinct cognitive modalities including working memory, attention, discrimination, and association. Importantly, touchscreen technology has allowed researchers to explore deficits in multiple pillars of cognition in a wide variety of perinatal disorders with neurological sequelae across critical developmental windows. The touchscreen platform has been used to dissect deficits in antenatal CNS injury including fetal alcohol syndrome, prenatal opioid exposure, and chorioamnionitis, to peripartum insults such as term hypoxic-ischemic encephalopathy, to early postnatal insults including infantile traumatic brain injury. Most importantly, touchscreen technology offers the sensitivity necessary to detect subtle injury and treatment-induced changes in cognition and executive function beyond those offered by more rudimentary tests of rodent cognition. Understanding the pathophysiology of these disorders in rodents is paramount to addressing these deficits in human infants and dissecting the neural circuitry essential to perinatal brain injury pathophysiology and responsiveness to novel therapeutics. Touchscreen testing provides an effective, facile, sophisticated technique to accelerate the goal of improving cognitive and behavioral outcomes of children who suffer perinatal brain injury.
KW - CANTAB
KW - Chorioamnionitis
KW - Perinatal brain injury
KW - Placenta
KW - Reversal learning
UR - http://www.scopus.com/inward/record.url?scp=85129721782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85129721782&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2022.114104
DO - 10.1016/j.expneurol.2022.114104
M3 - Article
C2 - 35525306
AN - SCOPUS:85129721782
SN - 0014-4886
VL - 354
JO - Experimental Neurology
JF - Experimental Neurology
M1 - 114104
ER -