Premier: A clinical trial of comprehensive lifestyle modification for blood pressure control: Rationale, design and baseline characteristics

Laura P. Svetkey; David W. Harsha; William M. Vollmer; Victor J. Stevens; Eva Obarzanek; Patricia J. Elmer; Pao Hwa Lin; Catherine Champagne; Denise G. Simons-Morton; Mikel Aickin; Michael A. Proschan; Lawrence J. Appel

doi:10.1016/S1047-2797(03)00006-1

Premier: A clinical trial of comprehensive lifestyle modification for blood pressure control: Rationale, design and baseline characteristics

Laura P. Svetkey, David W. Harsha, William M. Vollmer, Victor J. Stevens, Eva Obarzanek, Patricia J. Elmer, Pao Hwa Lin, Catherine Champagne, Denise G. Simons-Morton, Mikel Aickin, Michael A. Proschan, Lawrence J. Appel

School of Medicine

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

PURPOSE: To describe PREMIER, a randomized trial to determine the effects of multi-component lifestyle interventions on blood pressure (BP). METHODS: Participants with above optimal BP through stage 1 hypertension were randomized to: 1) a behavioral lifestyle (BLS) intervention that implements established recommendations, 2) a BLS intervention that implements established recommendations plus the DASH diet, or 3) an advice only standard of care group. The two BLS interventions consist of group and individual counseling sessions for 18 months. The primary outcome is systolic BP at 6 months. Additional outcomes include diastolic BP and homocysteine at 6 months; systolic and diastolic BP at 18 months; fasting lipids, glucose and insulin at 6 and 18 months; and effects in subgroup. CONCLUSION: Results from the PREMIER trial will provide scientific rationale for implementing multi-component behavioral lifestyle intervention programs to control BP and prevent CVD.

Original language	English (US)
Pages (from-to)	462-471
Number of pages	10
Journal	Annals of epidemiology
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/S1047-2797(03)00006-1
State	Published - Jul 2003

Keywords

Blood Pressure
Diet
Lifestyle
Weight Loss

ASJC Scopus subject areas

Epidemiology

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10.1016/S1047-2797(03)00006-1

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Svetkey, L. P., Harsha, D. W., Vollmer, W. M., Stevens, V. J., Obarzanek, E., Elmer, P. J., Lin, P. H., Champagne, C., Simons-Morton, D. G., Aickin, M., Proschan, M. A., & Appel, L. J. (2003). Premier: A clinical trial of comprehensive lifestyle modification for blood pressure control: Rationale, design and baseline characteristics. Annals of epidemiology, 13(6), 462-471. https://doi.org/10.1016/S1047-2797(03)00006-1

Svetkey, LP, Harsha, DW, Vollmer, WM, Stevens, VJ, Obarzanek, E, Elmer, PJ, Lin, PH, Champagne, C, Simons-Morton, DG, Aickin, M, Proschan, MA & Appel, LJ 2003, 'Premier: A clinical trial of comprehensive lifestyle modification for blood pressure control: Rationale, design and baseline characteristics', Annals of epidemiology, vol. 13, no. 6, pp. 462-471. https://doi.org/10.1016/S1047-2797(03)00006-1

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title = "Premier: A clinical trial of comprehensive lifestyle modification for blood pressure control: Rationale, design and baseline characteristics",

abstract = "PURPOSE: To describe PREMIER, a randomized trial to determine the effects of multi-component lifestyle interventions on blood pressure (BP). METHODS: Participants with above optimal BP through stage 1 hypertension were randomized to: 1) a behavioral lifestyle (BLS) intervention that implements established recommendations, 2) a BLS intervention that implements established recommendations plus the DASH diet, or 3) an advice only standard of care group. The two BLS interventions consist of group and individual counseling sessions for 18 months. The primary outcome is systolic BP at 6 months. Additional outcomes include diastolic BP and homocysteine at 6 months; systolic and diastolic BP at 18 months; fasting lipids, glucose and insulin at 6 and 18 months; and effects in subgroup. CONCLUSION: Results from the PREMIER trial will provide scientific rationale for implementing multi-component behavioral lifestyle intervention programs to control BP and prevent CVD.",

keywords = "Blood Pressure, Diet, Lifestyle, Weight Loss",

author = "Svetkey, {Laura P.} and Harsha, {David W.} and Vollmer, {William M.} and Stevens, {Victor J.} and Eva Obarzanek and Elmer, {Patricia J.} and Lin, {Pao Hwa} and Catherine Champagne and Simons-Morton, {Denise G.} and Mikel Aickin and Proschan, {Michael A.} and Appel, {Lawrence J.}",

note = "Funding Information: This work is supported by NIH grants UO1 HL60570, UO1 HL60571, UO1 HL60573, UO1 HL60574, UO1 HL62828.",

year = "2003",

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doi = "10.1016/S1047-2797(03)00006-1",

language = "English (US)",

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AU - Vollmer, William M.

AU - Stevens, Victor J.

AU - Obarzanek, Eva

AU - Elmer, Patricia J.

AU - Lin, Pao Hwa

AU - Champagne, Catherine

AU - Simons-Morton, Denise G.

AU - Aickin, Mikel

AU - Proschan, Michael A.

AU - Appel, Lawrence J.

N1 - Funding Information: This work is supported by NIH grants UO1 HL60570, UO1 HL60571, UO1 HL60573, UO1 HL60574, UO1 HL62828.

PY - 2003/7

Y1 - 2003/7

N2 - PURPOSE: To describe PREMIER, a randomized trial to determine the effects of multi-component lifestyle interventions on blood pressure (BP). METHODS: Participants with above optimal BP through stage 1 hypertension were randomized to: 1) a behavioral lifestyle (BLS) intervention that implements established recommendations, 2) a BLS intervention that implements established recommendations plus the DASH diet, or 3) an advice only standard of care group. The two BLS interventions consist of group and individual counseling sessions for 18 months. The primary outcome is systolic BP at 6 months. Additional outcomes include diastolic BP and homocysteine at 6 months; systolic and diastolic BP at 18 months; fasting lipids, glucose and insulin at 6 and 18 months; and effects in subgroup. CONCLUSION: Results from the PREMIER trial will provide scientific rationale for implementing multi-component behavioral lifestyle intervention programs to control BP and prevent CVD.

AB - PURPOSE: To describe PREMIER, a randomized trial to determine the effects of multi-component lifestyle interventions on blood pressure (BP). METHODS: Participants with above optimal BP through stage 1 hypertension were randomized to: 1) a behavioral lifestyle (BLS) intervention that implements established recommendations, 2) a BLS intervention that implements established recommendations plus the DASH diet, or 3) an advice only standard of care group. The two BLS interventions consist of group and individual counseling sessions for 18 months. The primary outcome is systolic BP at 6 months. Additional outcomes include diastolic BP and homocysteine at 6 months; systolic and diastolic BP at 18 months; fasting lipids, glucose and insulin at 6 and 18 months; and effects in subgroup. CONCLUSION: Results from the PREMIER trial will provide scientific rationale for implementing multi-component behavioral lifestyle intervention programs to control BP and prevent CVD.

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Premier: A clinical trial of comprehensive lifestyle modification for blood pressure control: Rationale, design and baseline characteristics

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