Premature ovarian failure associated with autoantibodies to the zona pellucida

S. Smith, S. Hosid

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Immune disturbances are noted in up to 35% of women with premature ovarian failure. Previous investigators have focused on the presence of antibodies directed against steroid secreting cells of the ovary and the presence of lymphocytic infiltration in ovarian biopsy specimens. The authors report two cases of premature ovarian failure associated with antibodies directed against the zona pellucida. One of these two patients conceived while on estrogen replacement therapy.

Original languageEnglish (US)
Pages (from-to)316-319
Number of pages4
JournalInternational Journal of Fertility and Menopausal Studies
Issue number6
StatePublished - Jan 1 1994
Externally publishedYes


  • (premature) ovarian failure
  • estrogen replacement therapy
  • immune system
  • zona pellucida antibodies

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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