Premature birth, homeostatic plasticity and respiratory consequences of inflammation

Estelle B. Gauda, Gabrielle L. McLemore

Research output: Contribution to journalReview article

Abstract

Infants who are born premature can have persistent apnea beyond term gestation, reemergence of apnea associated with inflammation during infancy, increased risk of sudden unexplained death, and sleep disorder breathing during infancy and childhood. The autonomic nervous system, particularly the central neural networks that control breathing and peripheral and central chemoreceptors and mechanoreceptors that modulate the activity of the central respiratory network, are rapidly developing during the last trimester (22–37 weeks gestation) of fetal life. With advances in neonatology, in well-resourced, developed countries, infants born as young as 23 weeks gestation can survive. Thus, a substantial part of maturation of central and peripheral systems that control breathing occurs ex-utero in infants born at the limit of viability. The balance of excitatory and inhibitory influences dictates the ultimate output from the central respiratory network. We propose in this review that simply being born early in the last trimester can trigger homeostatic plasticity within the respiratory network tipping the balance toward inhibition that persists in infancy. We discuss the intersection of premature birth, homeostatic plasticity and biological mechanisms leading to respiratory depression during inflammation in former premature infants.

Original languageEnglish (US)
Article number103337
JournalRespiratory Physiology and Neurobiology
Volume274
DOIs
StatePublished - Mar 2020
Externally publishedYes

Keywords

  • Apnea
  • Carotid body
  • Inflammation
  • Respiratory plasticity
  • Sudden infant death syndrome limit of viability

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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