TY - JOUR
T1 - Preliminary studies of the application of near infrared spectroscopy in the diagnosis of deep vein thrombosis
AU - Korah, Lino K.
AU - Scott, Frederick D.
AU - Williams, G. Melville
AU - Kang, Kyung A.
PY - 2003
Y1 - 2003
N2 - A feasibility study for diagnosing deep vein thrombosis utilizing near-infrared continuous wave spectroscopy was performed, as a real-time, non-invasive, and inexpensive method. The probe contains two light sources and two detectors with optical filters that monitor reflected light at wavelengths 760 and 850 nm to measure the changes in the amount of deoxyhemoglobin and oxyhemoglobin, respectively. These changes and the blood volume changes are recorded while the subject performs a series of light leg exercises. The test protocol is designed to determine the muscle tissue blood volume capacity, rate of blood filling (venous valve functionality test), and efficiency to promote one-directional venous flow from the leg to heart. The subject pool consists of the patients with leg deep vein thrombosis (DVT) diagnosed by the Johns Hopkins Hospital Vascular Surgery Department and of normal subjects as the control. Abnormal venous systems showed distinct characteristics: high blood volume in the leg; high rate of blood filling while the subject stands upright; and the inability to decrease the blood volume during the muscle contraction. The NIR device proved to be an inexpensive, effective, and portable device that can detect DVT in the leg in real-time.
AB - A feasibility study for diagnosing deep vein thrombosis utilizing near-infrared continuous wave spectroscopy was performed, as a real-time, non-invasive, and inexpensive method. The probe contains two light sources and two detectors with optical filters that monitor reflected light at wavelengths 760 and 850 nm to measure the changes in the amount of deoxyhemoglobin and oxyhemoglobin, respectively. These changes and the blood volume changes are recorded while the subject performs a series of light leg exercises. The test protocol is designed to determine the muscle tissue blood volume capacity, rate of blood filling (venous valve functionality test), and efficiency to promote one-directional venous flow from the leg to heart. The subject pool consists of the patients with leg deep vein thrombosis (DVT) diagnosed by the Johns Hopkins Hospital Vascular Surgery Department and of normal subjects as the control. Abnormal venous systems showed distinct characteristics: high blood volume in the leg; high rate of blood filling while the subject stands upright; and the inability to decrease the blood volume during the muscle contraction. The NIR device proved to be an inexpensive, effective, and portable device that can detect DVT in the leg in real-time.
KW - Blood Volume
KW - Deep Vein Thrombosis
KW - NIR spectroscopy
KW - Oxy- and deoxyhemoglobin
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U2 - 10.1007/978-1-4615-0075-9_70
DO - 10.1007/978-1-4615-0075-9_70
M3 - Article
C2 - 14562768
AN - SCOPUS:0242330379
SN - 0065-2598
VL - 530
SP - 697
EP - 706
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -