Preliminary report on cognitive and adaptive behaviors of preschool-aged males with fragile X

L. S. Freund, C. D. Peebles, Elizabeth H. Aylward, A. L. Reiss

Research output: Contribution to journalArticle

Abstract

Preliminary results are presented of 18 males with fragile X (fra X) syndrome between the ages of 16 and 64 months compared to non-fra X males individually matched on age and overall IQ. Cognitive assessments were conducted with either the Bayley Scales of Infant Development or the Stanford-Binet, 4th edition. Adaptive and maladaptive behaviors were assessed by the Vineland Adaptive Behavior Scales and the Child Behavior Checklist, respectively. Forty-four percent of the fra X group had overall IQs in the borderline to average ranges. In cognitive assessments with the Stanford-Binet, the fra X group scored lower than controls in quantitative and short-term memory areas. There was no evidence, however, that overall IQ declined among the fra X children across the 16 through 64 month age period. Older (≥ 40 months) fra X males scored lower in the communication and socialization adaptive behavior domains than younger (<40 months) fra X males and older controls. Among maladaptive behaviors, social withdrawal behaviors were most problematic for the young males with fra X. These preliminary findings indicate that a neurobehavioral profile in fra X males was observed as early as 3-5 years of age and adaptive behavior development appeared to slow during this same age period.

Original languageEnglish (US)
Pages (from-to)242-251
Number of pages10
JournalDevelopmental Brain Dysfunction
Volume8
Issue number4-6
StatePublished - 1995
Externally publishedYes

Fingerprint

Psychological Adaptation
Fragile X Syndrome
Socialization
Child Behavior
Child Development
Checklist
Short-Term Memory
Communication

Keywords

  • age preschool
  • behaviors cognitive, adaptive
  • fragile X
  • IQ

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Preliminary report on cognitive and adaptive behaviors of preschool-aged males with fragile X. / Freund, L. S.; Peebles, C. D.; Aylward, Elizabeth H.; Reiss, A. L.

In: Developmental Brain Dysfunction, Vol. 8, No. 4-6, 1995, p. 242-251.

Research output: Contribution to journalArticle

@article{cc6d4c8fe7d44d8384458bb4d8413b7b,
title = "Preliminary report on cognitive and adaptive behaviors of preschool-aged males with fragile X",
abstract = "Preliminary results are presented of 18 males with fragile X (fra X) syndrome between the ages of 16 and 64 months compared to non-fra X males individually matched on age and overall IQ. Cognitive assessments were conducted with either the Bayley Scales of Infant Development or the Stanford-Binet, 4th edition. Adaptive and maladaptive behaviors were assessed by the Vineland Adaptive Behavior Scales and the Child Behavior Checklist, respectively. Forty-four percent of the fra X group had overall IQs in the borderline to average ranges. In cognitive assessments with the Stanford-Binet, the fra X group scored lower than controls in quantitative and short-term memory areas. There was no evidence, however, that overall IQ declined among the fra X children across the 16 through 64 month age period. Older (≥ 40 months) fra X males scored lower in the communication and socialization adaptive behavior domains than younger (<40 months) fra X males and older controls. Among maladaptive behaviors, social withdrawal behaviors were most problematic for the young males with fra X. These preliminary findings indicate that a neurobehavioral profile in fra X males was observed as early as 3-5 years of age and adaptive behavior development appeared to slow during this same age period.",
keywords = "age preschool, behaviors cognitive, adaptive, fragile X, IQ",
author = "Freund, {L. S.} and Peebles, {C. D.} and Aylward, {Elizabeth H.} and Reiss, {A. L.}",
year = "1995",
language = "English (US)",
volume = "8",
pages = "242--251",
journal = "Developmental Brain Dysfunction",
issn = "1019-5815",
publisher = "S. Karger AG",
number = "4-6",

}

TY - JOUR

T1 - Preliminary report on cognitive and adaptive behaviors of preschool-aged males with fragile X

AU - Freund, L. S.

AU - Peebles, C. D.

AU - Aylward, Elizabeth H.

AU - Reiss, A. L.

PY - 1995

Y1 - 1995

N2 - Preliminary results are presented of 18 males with fragile X (fra X) syndrome between the ages of 16 and 64 months compared to non-fra X males individually matched on age and overall IQ. Cognitive assessments were conducted with either the Bayley Scales of Infant Development or the Stanford-Binet, 4th edition. Adaptive and maladaptive behaviors were assessed by the Vineland Adaptive Behavior Scales and the Child Behavior Checklist, respectively. Forty-four percent of the fra X group had overall IQs in the borderline to average ranges. In cognitive assessments with the Stanford-Binet, the fra X group scored lower than controls in quantitative and short-term memory areas. There was no evidence, however, that overall IQ declined among the fra X children across the 16 through 64 month age period. Older (≥ 40 months) fra X males scored lower in the communication and socialization adaptive behavior domains than younger (<40 months) fra X males and older controls. Among maladaptive behaviors, social withdrawal behaviors were most problematic for the young males with fra X. These preliminary findings indicate that a neurobehavioral profile in fra X males was observed as early as 3-5 years of age and adaptive behavior development appeared to slow during this same age period.

AB - Preliminary results are presented of 18 males with fragile X (fra X) syndrome between the ages of 16 and 64 months compared to non-fra X males individually matched on age and overall IQ. Cognitive assessments were conducted with either the Bayley Scales of Infant Development or the Stanford-Binet, 4th edition. Adaptive and maladaptive behaviors were assessed by the Vineland Adaptive Behavior Scales and the Child Behavior Checklist, respectively. Forty-four percent of the fra X group had overall IQs in the borderline to average ranges. In cognitive assessments with the Stanford-Binet, the fra X group scored lower than controls in quantitative and short-term memory areas. There was no evidence, however, that overall IQ declined among the fra X children across the 16 through 64 month age period. Older (≥ 40 months) fra X males scored lower in the communication and socialization adaptive behavior domains than younger (<40 months) fra X males and older controls. Among maladaptive behaviors, social withdrawal behaviors were most problematic for the young males with fra X. These preliminary findings indicate that a neurobehavioral profile in fra X males was observed as early as 3-5 years of age and adaptive behavior development appeared to slow during this same age period.

KW - age preschool

KW - behaviors cognitive, adaptive

KW - fragile X

KW - IQ

UR - http://www.scopus.com/inward/record.url?scp=0029549970&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029549970&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0029549970

VL - 8

SP - 242

EP - 251

JO - Developmental Brain Dysfunction

JF - Developmental Brain Dysfunction

SN - 1019-5815

IS - 4-6

ER -