Preliminary findings of altered functional connectivity of the default mode network linked to functional outcomes one year after pediatric traumatic brain injury

Jaclyn A. Stephens, Cynthia F Salorio, Anita D. Barber, Sarah R. Risen, Stewart H Mostofsky, Stacy Jennifer M Suskauer

Research output: Contribution to journalArticle

Abstract

Purpose and Method: This study examined functional connectivity of the default mode network (DMN) and examined brain–behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI). Results: Compared to uninjured peers, children with TBI demonstrated less anti-correlated functional connectivity between DMN and right Brodmann Area 40 (BA 40). In children with TBI, more anomalous less anti-correlated) connectivity between DMN and right BA 40 was linked to poorer performance on response inhibition tasks. Conclusion: Collectively, these preliminary findings suggest that functional connectivity between DMN and BA 40 may relate to longterm functional outcomes in chronic pediatric TBI.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalDevelopmental Neurorehabilitation
DOIs
StateAccepted/In press - Jul 10 2017

Keywords

  • Functional neuroimaging
  • mild traumatic brain injury
  • moderate traumatic brain injury
  • neural networks
  • response inhibition

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Rehabilitation
  • Developmental Neuroscience

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