Preliminary experience with chemotherapy in advanced salivary gland neoplasms

Chandra P. Belani, Mario A. Eisenberger, William C. Gray

Research output: Contribution to journalArticlepeer-review

Abstract

Eight patients with advanced incurable salivary gland carcinoma were treated with the combination of cyclophosphamide, doxorubicin, and cisplatin (CAP). There were three clinical complete responses and two excellent partial responses. One of the three nonresponders had symptomatic improvement without any response in the measurable disease sites. Side effects were acceptable. All patients had moderate nausea and some degree of vomiting, which were adequately controlled by antiemetics. These results are preliminary but when considered with other reported trials using the same combination suggest an active treatment program for advanced neoplasms of the salivary glands.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalMedical and Pediatric Oncology
Volume16
Issue number3
DOIs
StatePublished - 1988
Externally publishedYes

Keywords

  • combination chemotherapy
  • salivary gland neoplasms

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

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