Preliminary Effectiveness of Auricular Point Acupressure on Chemotherapy-Induced Neuropathy: Part 2 Laboratory-Assessed and Objective Outcomes

Chao Hsing Yeh, Nada Lukkahatai, Claudia Campbell, Haris Sair, Fengzhi Zhang, Sylvanus Mensah, Courtney Garry, Jing Zeng, Changying Chen, Mariela Pinedo, Mohammad Khoshnoodi, Nancy Perrin, Thomas J. Smith, Leorey N. Saligan

Research output: Contribution to journalArticlepeer-review


Purpose: To manage chemotherapy-induced neuropathy (CIN), this paper explores reliable and valid objectives measures to evaluate the treatment effects of auricular point acupressure (APA). Design/Method: This study was a repeated-measures one-group design. Participants received four weeks of APA to manage their CIN. The laboratory-assessed and objective outcomes included quantitative sensory testing, grip and pinch strength, and inflammatory biomarkers. Wilcoxon matched pairs signed-rank tests were conducted to determine change scores of outcomes at pre- vs. post- and pre- vs. 1-month follow-up. Spearman's rho correlation coefficient was used to examine the linear association of score changes of all objective study outcomes. Results: Comparing pre-and-post APA, (1) the mean score of the monofilament for all lower extremity sites tested decreased after APA, indicating sensory improvement; (2) the suprathreshold pinprick stimuli mean scores on the upper extremities increased, except the scores from the index finger and thumb; (3) the pain tolerance of thumb and trapezius areas increased; (4) decreasing IL1β (p =.05), IFNγ (p =.02), IL-2 (p =.03), IL-6 (p =.05), IL-10 (p =.05), and IP10/CXCL10 (p =.04) were observed pre-post APA. Conditional pain modulation was significantly (p<.05) associated with pain intensity (r = 0.55), tingling (r = 0.59); and IL1β concentration (r = 0.53) pre-post APA. The sustained effects of 4-week APA were observed at the 1-month follow-up. Conclusions: Our study findings demonstrated the promising effectiveness of APA in the management of CIN, and these treatment effects can be assessed using reliable and valid objective measures. Clinical Implications: If the efficacy of APA to manage CIN is confirmed in a larger sample, APA has the potential to be a scalable treatment for CIN because it is a reproducible, standardized, and easy-to-perform intervention.

Original languageEnglish (US)
Pages (from-to)623-632
Number of pages10
JournalPain Management Nursing
Issue number6
StatePublished - Dec 2019

ASJC Scopus subject areas

  • Advanced and Specialized Nursing


Dive into the research topics of 'Preliminary Effectiveness of Auricular Point Acupressure on Chemotherapy-Induced Neuropathy: Part 2 Laboratory-Assessed and Objective Outcomes'. Together they form a unique fingerprint.

Cite this