TY - JOUR
T1 - Preliminary Effectiveness of Auricular Point Acupressure on Chemotherapy-Induced Neuropathy
T2 - Part 2 Laboratory-Assessed and Objective Outcomes
AU - Yeh, Chao Hsing
AU - Lukkahatai, Nada
AU - Campbell, Claudia
AU - Sair, Haris
AU - Zhang, Fengzhi
AU - Mensah, Sylvanus
AU - Garry, Courtney
AU - Zeng, Jing
AU - Chen, Changying
AU - Pinedo, Mariela
AU - Khoshnoodi, Mohammad
AU - Perrin, Nancy
AU - Smith, Thomas J.
AU - Saligan, Leorey N.
N1 - Funding Information:
This study was supported by a grant to Dr. Yeh from the Johns Hopkins Discovery Award.
Publisher Copyright:
© 2019 American Society for Pain Management Nursing
PY - 2019/12
Y1 - 2019/12
N2 - Purpose: To manage chemotherapy-induced neuropathy (CIN), this paper explores reliable and valid objectives measures to evaluate the treatment effects of auricular point acupressure (APA). Design/Method: This study was a repeated-measures one-group design. Participants received four weeks of APA to manage their CIN. The laboratory-assessed and objective outcomes included quantitative sensory testing, grip and pinch strength, and inflammatory biomarkers. Wilcoxon matched pairs signed-rank tests were conducted to determine change scores of outcomes at pre- vs. post- and pre- vs. 1-month follow-up. Spearman's rho correlation coefficient was used to examine the linear association of score changes of all objective study outcomes. Results: Comparing pre-and-post APA, (1) the mean score of the monofilament for all lower extremity sites tested decreased after APA, indicating sensory improvement; (2) the suprathreshold pinprick stimuli mean scores on the upper extremities increased, except the scores from the index finger and thumb; (3) the pain tolerance of thumb and trapezius areas increased; (4) decreasing IL1β (p =.05), IFNγ (p =.02), IL-2 (p =.03), IL-6 (p =.05), IL-10 (p =.05), and IP10/CXCL10 (p =.04) were observed pre-post APA. Conditional pain modulation was significantly (p<.05) associated with pain intensity (r = 0.55), tingling (r = 0.59); and IL1β concentration (r = 0.53) pre-post APA. The sustained effects of 4-week APA were observed at the 1-month follow-up. Conclusions: Our study findings demonstrated the promising effectiveness of APA in the management of CIN, and these treatment effects can be assessed using reliable and valid objective measures. Clinical Implications: If the efficacy of APA to manage CIN is confirmed in a larger sample, APA has the potential to be a scalable treatment for CIN because it is a reproducible, standardized, and easy-to-perform intervention.
AB - Purpose: To manage chemotherapy-induced neuropathy (CIN), this paper explores reliable and valid objectives measures to evaluate the treatment effects of auricular point acupressure (APA). Design/Method: This study was a repeated-measures one-group design. Participants received four weeks of APA to manage their CIN. The laboratory-assessed and objective outcomes included quantitative sensory testing, grip and pinch strength, and inflammatory biomarkers. Wilcoxon matched pairs signed-rank tests were conducted to determine change scores of outcomes at pre- vs. post- and pre- vs. 1-month follow-up. Spearman's rho correlation coefficient was used to examine the linear association of score changes of all objective study outcomes. Results: Comparing pre-and-post APA, (1) the mean score of the monofilament for all lower extremity sites tested decreased after APA, indicating sensory improvement; (2) the suprathreshold pinprick stimuli mean scores on the upper extremities increased, except the scores from the index finger and thumb; (3) the pain tolerance of thumb and trapezius areas increased; (4) decreasing IL1β (p =.05), IFNγ (p =.02), IL-2 (p =.03), IL-6 (p =.05), IL-10 (p =.05), and IP10/CXCL10 (p =.04) were observed pre-post APA. Conditional pain modulation was significantly (p<.05) associated with pain intensity (r = 0.55), tingling (r = 0.59); and IL1β concentration (r = 0.53) pre-post APA. The sustained effects of 4-week APA were observed at the 1-month follow-up. Conclusions: Our study findings demonstrated the promising effectiveness of APA in the management of CIN, and these treatment effects can be assessed using reliable and valid objective measures. Clinical Implications: If the efficacy of APA to manage CIN is confirmed in a larger sample, APA has the potential to be a scalable treatment for CIN because it is a reproducible, standardized, and easy-to-perform intervention.
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U2 - 10.1016/j.pmn.2019.04.004
DO - 10.1016/j.pmn.2019.04.004
M3 - Article
C2 - 31204029
AN - SCOPUS:85067207407
SN - 1524-9042
VL - 20
SP - 623
EP - 632
JO - Pain Management Nursing
JF - Pain Management Nursing
IS - 6
ER -