Preliminary assessment of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with bladder cancer

Shigeru Kosuda, Paul V. Kison, Robert Greenough, H. Barton Grossman, Richard L. Wahl

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to assess the feasibility of imaging of bladder cancer with fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) scanning, We studied 12 patients with histologically proven bladder cancer who had undergone surgical procedures and/or radiotherapy. Retrograde irrigation of the urinary bladder with 1000-3710 ml saline was performed during nine of the studies. Dynamic and static PET images were obtained, and standardized uptake value images were reconstructed, FDG-PET scanning was true-positive in eight patients (66.7%), but false-negative in four (33.3%). Of 20 organs with tumor mass lesions confirmed pathologically or clinically, 16 (80%) were detected by FDG-PET scanning. FDG-PET scanning detected all of 17 distant metastatic lesions and two of three proven regional lymph node metastases. FDG-PET was also capable of differentiating viable recurrent bladder cancer from radiation-induced alterations in two patients. In conclusion, these preliminary data indicate the feasibility of FDG-PET imaging in patients with bladder cancer, although a major remaining pitfall is intense FDG accumulation in the urine.

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
JournalEuropean Journal Of Nuclear Medicine
Volume24
Issue number6
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Urinary Bladder Neoplasms
Positron-Emission Tomography
Urinary Bladder
Radiotherapy
Lymph Nodes
Urine
Radiation
Neoplasm Metastasis
Neoplasms

Keywords

  • Bladder cancer
  • Fluorine-18 fluorodeoxyglucose
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Preliminary assessment of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with bladder cancer. / Kosuda, Shigeru; Kison, Paul V.; Greenough, Robert; Grossman, H. Barton; Wahl, Richard L.

In: European Journal Of Nuclear Medicine, Vol. 24, No. 6, 1997, p. 615-620.

Research output: Contribution to journalArticle

Kosuda, Shigeru ; Kison, Paul V. ; Greenough, Robert ; Grossman, H. Barton ; Wahl, Richard L. / Preliminary assessment of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with bladder cancer. In: European Journal Of Nuclear Medicine. 1997 ; Vol. 24, No. 6. pp. 615-620.
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