Pregnant women & vaccines against emerging epidemic threats

Ethics guidance for preparedness, research, and response

The PREVENT Working Group

Research output: Contribution to journalReview article

Abstract

Zika virus, influenza, and Ebola have called attention to the ways in which infectious disease outbreaks can severely – and at times uniquely – affect the health interests of pregnant women and their offspring. These examples also highlight the critical need to proactively consider pregnant women and their offspring in vaccine research and response efforts to combat emerging and re-emerging infectious diseases. Historically, pregnant women and their offspring have been largely excluded from research agendas and investment strategies for vaccines against epidemic threats, which in turn can lead to exclusion from future vaccine campaigns amidst outbreaks. This state of affairs is profoundly unjust to pregnant women and their offspring, and deeply problematic from the standpoint of public health. To ensure that the needs of pregnant women and their offspring are fairly addressed, new approaches to public health preparedness, vaccine research and development, and vaccine delivery are required. This Guidance offers 22 concrete recommendations that provide a roadmap for the ethically responsible, socially just, and respectful inclusion of the interests of pregnant women in the development and deployment of vaccines against emerging pathogens. The Guidance was developed by the Pregnancy Research Ethics for Vaccines, Epidemics, and New Technologies (PREVENT) Working Group – a multidisciplinary, international team of 17 experts specializing in bioethics, maternal immunization, maternal-fetal medicine, obstetrics, pediatrics, philosophy, public health, and vaccine research and policy – in consultation with a variety of external experts and stakeholders.

Original languageEnglish (US)
JournalVaccine
DOIs
StatePublished - Jan 1 2019

Fingerprint

ethics
pregnant women
Ethics
Pregnant Women
Vaccines
vaccines
Research
public health
Public Health
Zika virus
Disease Outbreaks
Mothers
bioethics
Emerging Communicable Diseases
Research Ethics
Bioethics
emerging diseases
research and development
influenza
stakeholders

Keywords

  • Emerging infectious diseases
  • Epidemics
  • Maternal immunization
  • Pregnancy
  • Public health ethics
  • Research & development
  • Research ethics
  • Vaccines

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Pregnant women & vaccines against emerging epidemic threats : Ethics guidance for preparedness, research, and response. / The PREVENT Working Group.

In: Vaccine, 01.01.2019.

Research output: Contribution to journalReview article

@article{e00216da160f412c93ebaaf33f1dddfe,
title = "Pregnant women & vaccines against emerging epidemic threats: Ethics guidance for preparedness, research, and response",
abstract = "Zika virus, influenza, and Ebola have called attention to the ways in which infectious disease outbreaks can severely – and at times uniquely – affect the health interests of pregnant women and their offspring. These examples also highlight the critical need to proactively consider pregnant women and their offspring in vaccine research and response efforts to combat emerging and re-emerging infectious diseases. Historically, pregnant women and their offspring have been largely excluded from research agendas and investment strategies for vaccines against epidemic threats, which in turn can lead to exclusion from future vaccine campaigns amidst outbreaks. This state of affairs is profoundly unjust to pregnant women and their offspring, and deeply problematic from the standpoint of public health. To ensure that the needs of pregnant women and their offspring are fairly addressed, new approaches to public health preparedness, vaccine research and development, and vaccine delivery are required. This Guidance offers 22 concrete recommendations that provide a roadmap for the ethically responsible, socially just, and respectful inclusion of the interests of pregnant women in the development and deployment of vaccines against emerging pathogens. The Guidance was developed by the Pregnancy Research Ethics for Vaccines, Epidemics, and New Technologies (PREVENT) Working Group – a multidisciplinary, international team of 17 experts specializing in bioethics, maternal immunization, maternal-fetal medicine, obstetrics, pediatrics, philosophy, public health, and vaccine research and policy – in consultation with a variety of external experts and stakeholders.",
keywords = "Emerging infectious diseases, Epidemics, Maternal immunization, Pregnancy, Public health ethics, Research & development, Research ethics, Vaccines",
author = "{The PREVENT Working Group} and Krubiner, {Carleigh B.} and Faden, {Ruth R} and Karron, {Ruth A} and Little, {Margaret O.} and Lyerly, {Anne D.} and Abramson, {Jon S.} and Beigi, {Richard H.} and Cravioto, {Alejandro R.} and Durbin, {Anna P} and Gellin, {Bruce G.} and Gupta, {Swati B.} and Kaslow, {David C.} and Sonali Kochhar and Florencia Luna and Carla Saenz and Jeanne Sheffield and Tindana, {Paulina O.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.vaccine.2019.01.011",
language = "English (US)",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Pregnant women & vaccines against emerging epidemic threats

T2 - Ethics guidance for preparedness, research, and response

AU - The PREVENT Working Group

AU - Krubiner, Carleigh B.

AU - Faden, Ruth R

AU - Karron, Ruth A

AU - Little, Margaret O.

AU - Lyerly, Anne D.

AU - Abramson, Jon S.

AU - Beigi, Richard H.

AU - Cravioto, Alejandro R.

AU - Durbin, Anna P

AU - Gellin, Bruce G.

AU - Gupta, Swati B.

AU - Kaslow, David C.

AU - Kochhar, Sonali

AU - Luna, Florencia

AU - Saenz, Carla

AU - Sheffield, Jeanne

AU - Tindana, Paulina O.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Zika virus, influenza, and Ebola have called attention to the ways in which infectious disease outbreaks can severely – and at times uniquely – affect the health interests of pregnant women and their offspring. These examples also highlight the critical need to proactively consider pregnant women and their offspring in vaccine research and response efforts to combat emerging and re-emerging infectious diseases. Historically, pregnant women and their offspring have been largely excluded from research agendas and investment strategies for vaccines against epidemic threats, which in turn can lead to exclusion from future vaccine campaigns amidst outbreaks. This state of affairs is profoundly unjust to pregnant women and their offspring, and deeply problematic from the standpoint of public health. To ensure that the needs of pregnant women and their offspring are fairly addressed, new approaches to public health preparedness, vaccine research and development, and vaccine delivery are required. This Guidance offers 22 concrete recommendations that provide a roadmap for the ethically responsible, socially just, and respectful inclusion of the interests of pregnant women in the development and deployment of vaccines against emerging pathogens. The Guidance was developed by the Pregnancy Research Ethics for Vaccines, Epidemics, and New Technologies (PREVENT) Working Group – a multidisciplinary, international team of 17 experts specializing in bioethics, maternal immunization, maternal-fetal medicine, obstetrics, pediatrics, philosophy, public health, and vaccine research and policy – in consultation with a variety of external experts and stakeholders.

AB - Zika virus, influenza, and Ebola have called attention to the ways in which infectious disease outbreaks can severely – and at times uniquely – affect the health interests of pregnant women and their offspring. These examples also highlight the critical need to proactively consider pregnant women and their offspring in vaccine research and response efforts to combat emerging and re-emerging infectious diseases. Historically, pregnant women and their offspring have been largely excluded from research agendas and investment strategies for vaccines against epidemic threats, which in turn can lead to exclusion from future vaccine campaigns amidst outbreaks. This state of affairs is profoundly unjust to pregnant women and their offspring, and deeply problematic from the standpoint of public health. To ensure that the needs of pregnant women and their offspring are fairly addressed, new approaches to public health preparedness, vaccine research and development, and vaccine delivery are required. This Guidance offers 22 concrete recommendations that provide a roadmap for the ethically responsible, socially just, and respectful inclusion of the interests of pregnant women in the development and deployment of vaccines against emerging pathogens. The Guidance was developed by the Pregnancy Research Ethics for Vaccines, Epidemics, and New Technologies (PREVENT) Working Group – a multidisciplinary, international team of 17 experts specializing in bioethics, maternal immunization, maternal-fetal medicine, obstetrics, pediatrics, philosophy, public health, and vaccine research and policy – in consultation with a variety of external experts and stakeholders.

KW - Emerging infectious diseases

KW - Epidemics

KW - Maternal immunization

KW - Pregnancy

KW - Public health ethics

KW - Research & development

KW - Research ethics

KW - Vaccines

UR - http://www.scopus.com/inward/record.url?scp=85065024322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065024322&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2019.01.011

DO - 10.1016/j.vaccine.2019.01.011

M3 - Review article

JO - Vaccine

JF - Vaccine

SN - 0264-410X

ER -