Pregnancy modifies the antibody response to trivalent influenza immunization

Elizabeth P. Schlaudecker, Monica M. McNeal, Caitlin N. Dodd, Joseph B. Ranz, Mark C. Steinhoff

Research output: Contribution to journalArticlepeer-review

Abstract

We report the immunogenicity of trivalent influenza immunization in 29 pregnant women compared with 22 nonpregnant women. We obtained blood specimens on day 0 prior to 2011-2012 influenza vaccine administration and day 28 after immunization. Hemagglutination inhibition (HAI) geometric mean titers were similar before immunization but were significantly reduced by 40-50 in pregnant women after immunization for influenza A/California(H1N1) (P =. 027) and A/Perth(H3N2) (P =. 037). Postimmunization HAI titers were similar between groups for influenza B/Brisbane (P =. 390). The geometric mean ratio (fold increase) for influenza A(H1N1) was nonsignificantly reduced in pregnant participants (P =. 089). The percentages of participants who seroconverted and achieved seroprotection were similar between groups.

Original languageEnglish (US)
Pages (from-to)1670-1673
Number of pages4
JournalJournal of Infectious Diseases
Volume206
Issue number11
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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