Abstract
We report the immunogenicity of trivalent influenza immunization in 29 pregnant women compared with 22 nonpregnant women. We obtained blood specimens on day 0 prior to 2011-2012 influenza vaccine administration and day 28 after immunization. Hemagglutination inhibition (HAI) geometric mean titers were similar before immunization but were significantly reduced by 40-50 in pregnant women after immunization for influenza A/California(H1N1) (P =. 027) and A/Perth(H3N2) (P =. 037). Postimmunization HAI titers were similar between groups for influenza B/Brisbane (P =. 390). The geometric mean ratio (fold increase) for influenza A(H1N1) was nonsignificantly reduced in pregnant participants (P =. 089). The percentages of participants who seroconverted and achieved seroprotection were similar between groups.
Original language | English (US) |
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Pages (from-to) | 1670-1673 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 206 |
Issue number | 11 |
DOIs | |
State | Published - Dec 1 2012 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases