Pregnancy in patients with systemic sclerosis

Despite early literature suggesting an increased risk of infertility and significant pregnancy complications, favorable obstetric and neonatal outcomes can be achieved in patients with scleroderma. Commonly reported complications include prematurity and intrauterine growth restriction, and most of the adverse pregnancy outcomes occur in women with early, diffuse systemic sclerosis. Ideally, patients should undergo preconception counseling to determine if multi-organ involvement precludes pregnancy. A multidisciplinary approach including consultation with Maternal-Fetal Medicine, Rheumatology, and Anesthesiology are important to optimize patient's condition and provide recommendations for antepartum, intrapartum, and postpartum management. With appropriate care, women with systemic sclerosis can achieve successful pregnancy outcomes.