Pregnancy in autosomal recessive polycystic kidney disease

Nicole Banks, Joy Bryant, Roxanne Fischer, Marjan Huizing, William A. Gahl, Meral Gunay-Aygun

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Autosomal recessive polycystic kidney disease (ARPKD) is the most common childhood-onset ciliopathy. As treatments improve, more women are reaching reproductive age, but little is known about ARPKD and pregnancy.

Methods: In our ongoing study on ARPKD and other ciliopathies, 12 females over 18 years of age were identified and systematically evaluated. Six had children; four carried pregnancies and delivered, one used assisted reproductive technology and had a surrogate carry the pregnancy, and one adopted. We report the outcomes of four pregnancies with live birth deliveries and two women who chose alternate family building options.

Results: Patient one was diagnosed at 6 months, and at age 21 had a pregnancy complicated by transient worsening of renal function (creatinine increase from 1.15 to 1.78 mg/dL). Patient two was diagnosed with ARPKD at age seven and had an uncomplicated pregnancy at age 23. Patient three was diagnosed incidentally with ARPKD at age 23, 3 months after completion of an uncomplicated pregnancy. Patient four who had an uncomplicated pregnancy at age 33 was diagnosed with ARPKD at age 46.

Conclusions: Women with ARPKD face reproductive decisions largely bereft of information about the pregnancies of other ARPKD patients. We report four cases of pregnancy and ARPKD to expand current knowledge and encourage further research.

Original languageEnglish (US)
Pages (from-to)705-708
Number of pages4
JournalArchives of Gynecology and Obstetrics
Volume291
Issue number3
DOIs
StatePublished - Mar 2015
Externally publishedYes

Keywords

  • Autosomal recessive polycystic kidney disease (ARPKD)
  • Ciliopathy
  • Liver disease and pregnancy
  • Renal disease and pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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