Pregnancy and infection: Using disease pathogenesis to inform vaccine strategy

Meghan S. Vermillion, Sabra L. Klein

Research output: Contribution to journalReview article

Abstract

Vaccination is the mainstay of preventative medicine for many infectious diseases. Pregnant women, unborn fetuses, and neonates represent three at-risk populations that can be simultaneously protected by strategic vaccination protocols. Because the pathogenesis of different infectious microbes varies based on tissue tropism, timing of infection, and host susceptibility, the goals of immunization are not uniform across all vaccines. Mechanistic understanding of infectious disease pathogenesis and immune responses is therefore essential to inform vaccine design and the implementation of appropriate immunization protocols that optimize protection of pregnant women, fetuses, and neonates.

Original languageEnglish (US)
Article number6
Journalnpj Vaccines
Volume3
Issue number1
DOIs
StatePublished - Dec 1 2018

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

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