Prefrontal modulation of tactile responses in the ventrobasal thalamus of rats

Xiao Hua Cao; De Heng Wang; Jing Bai; Shao Ci Zhou; Yong Di Zhou

doi:10.1016/j.neulet.2008.02.030

Prefrontal modulation of tactile responses in the ventrobasal thalamus of rats

Xiao Hua Cao, De Heng Wang, Jing Bai, Shao Ci Zhou, Yong Di Zhou

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Prefrontal cortex (PFC) has been implicated in modulation of sensory information processing in somatosensory cortex. However, it remains unclear whether or not PFC regulates sensory information in thalamus. In the present study, the effect of PFC stimulation on tactile responses of neurons in the ventrobasal thalamus (VB) of the rat was investigated by single-unit recording. PFC stimulation significantly enhanced the signal-noise ratio (tactile responses/background activities) in 16 out of 66 VB neurons (24.2%) that had receptive fields in fore or hind limbs. Such changes can be classified into three different categories: (1) PFC stimulation not only increased the tactile responses, but also suppressed the background activities of neurons (six neurons, 9.1%); (2) PFC stimulation only increased the tactile responses of neurons (five neurons, 7.6%); (3) PFC stimulation only suppressed the background activities of neurons (five neurons, 7.6%). Our results suggest that PFC also modulates somatosensory information at the thalamic level.

Original language	English (US)
Pages (from-to)	152-157
Number of pages	6
Journal	Neuroscience Letters
Volume	435
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2008.02.030
State	Published - Apr 18 2008
Externally published	Yes

Keywords

Prefrontal cortex
Rats
Tactile response
Ventrobasal thalamus

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2008.02.030

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title = "Prefrontal modulation of tactile responses in the ventrobasal thalamus of rats",

abstract = "Prefrontal cortex (PFC) has been implicated in modulation of sensory information processing in somatosensory cortex. However, it remains unclear whether or not PFC regulates sensory information in thalamus. In the present study, the effect of PFC stimulation on tactile responses of neurons in the ventrobasal thalamus (VB) of the rat was investigated by single-unit recording. PFC stimulation significantly enhanced the signal-noise ratio (tactile responses/background activities) in 16 out of 66 VB neurons (24.2%) that had receptive fields in fore or hind limbs. Such changes can be classified into three different categories: (1) PFC stimulation not only increased the tactile responses, but also suppressed the background activities of neurons (six neurons, 9.1%); (2) PFC stimulation only increased the tactile responses of neurons (five neurons, 7.6%); (3) PFC stimulation only suppressed the background activities of neurons (five neurons, 7.6%). Our results suggest that PFC also modulates somatosensory information at the thalamic level.",

keywords = "Prefrontal cortex, Rats, Tactile response, Ventrobasal thalamus",

author = "Cao, {Xiao Hua} and Wang, {De Heng} and Jing Bai and Zhou, {Shao Ci} and Zhou, {Yong Di}",

year = "2008",

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language = "English (US)",

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AU - Cao, Xiao Hua

AU - Wang, De Heng

AU - Bai, Jing

AU - Zhou, Shao Ci

AU - Zhou, Yong Di

PY - 2008/4/18

Y1 - 2008/4/18

N2 - Prefrontal cortex (PFC) has been implicated in modulation of sensory information processing in somatosensory cortex. However, it remains unclear whether or not PFC regulates sensory information in thalamus. In the present study, the effect of PFC stimulation on tactile responses of neurons in the ventrobasal thalamus (VB) of the rat was investigated by single-unit recording. PFC stimulation significantly enhanced the signal-noise ratio (tactile responses/background activities) in 16 out of 66 VB neurons (24.2%) that had receptive fields in fore or hind limbs. Such changes can be classified into three different categories: (1) PFC stimulation not only increased the tactile responses, but also suppressed the background activities of neurons (six neurons, 9.1%); (2) PFC stimulation only increased the tactile responses of neurons (five neurons, 7.6%); (3) PFC stimulation only suppressed the background activities of neurons (five neurons, 7.6%). Our results suggest that PFC also modulates somatosensory information at the thalamic level.

AB - Prefrontal cortex (PFC) has been implicated in modulation of sensory information processing in somatosensory cortex. However, it remains unclear whether or not PFC regulates sensory information in thalamus. In the present study, the effect of PFC stimulation on tactile responses of neurons in the ventrobasal thalamus (VB) of the rat was investigated by single-unit recording. PFC stimulation significantly enhanced the signal-noise ratio (tactile responses/background activities) in 16 out of 66 VB neurons (24.2%) that had receptive fields in fore or hind limbs. Such changes can be classified into three different categories: (1) PFC stimulation not only increased the tactile responses, but also suppressed the background activities of neurons (six neurons, 9.1%); (2) PFC stimulation only increased the tactile responses of neurons (five neurons, 7.6%); (3) PFC stimulation only suppressed the background activities of neurons (five neurons, 7.6%). Our results suggest that PFC also modulates somatosensory information at the thalamic level.

KW - Prefrontal cortex

KW - Rats

KW - Tactile response

KW - Ventrobasal thalamus

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Prefrontal modulation of tactile responses in the ventrobasal thalamus of rats

Abstract

Keywords

ASJC Scopus subject areas

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