Prefrontal modulation of tactile responses in the ventrobasal thalamus of rats

Xiao Hua Cao, De Heng Wang, Jing Bai, Shao Ci Zhou, Yong Di Zhou

Research output: Contribution to journalArticlepeer-review

Abstract

Prefrontal cortex (PFC) has been implicated in modulation of sensory information processing in somatosensory cortex. However, it remains unclear whether or not PFC regulates sensory information in thalamus. In the present study, the effect of PFC stimulation on tactile responses of neurons in the ventrobasal thalamus (VB) of the rat was investigated by single-unit recording. PFC stimulation significantly enhanced the signal-noise ratio (tactile responses/background activities) in 16 out of 66 VB neurons (24.2%) that had receptive fields in fore or hind limbs. Such changes can be classified into three different categories: (1) PFC stimulation not only increased the tactile responses, but also suppressed the background activities of neurons (six neurons, 9.1%); (2) PFC stimulation only increased the tactile responses of neurons (five neurons, 7.6%); (3) PFC stimulation only suppressed the background activities of neurons (five neurons, 7.6%). Our results suggest that PFC also modulates somatosensory information at the thalamic level.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalNeuroscience Letters
Volume435
Issue number2
DOIs
StatePublished - Apr 18 2008
Externally publishedYes

Keywords

  • Prefrontal cortex
  • Rats
  • Tactile response
  • Ventrobasal thalamus

ASJC Scopus subject areas

  • Neuroscience(all)

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