Prefrontal cortical blood flow and cognitive function in Huntington's disease

D. R. Weinberger, K. F. Berman, M. Iadarola, N. Driesen, R. F. Zec

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


To examine the relationship between cortical physiology and dementia in Huntington's disease rCBF during three different behavioural conditions, one of which emphasised prefrontal cognition, was determined by xenon-133 inhalation in 14 patients with Huntington's disease and in matched controls. Cortical rCBF was not reduced in Huntington's disease patients even while they manifested overt prefrontal-type cognitive deficits. Caudate atrophy on CT and rCBF were significantly correlated, but only during the prefrontal behaviour where the correlation was positive. These results suggets a qualification of the subcortical dementia concept as applied to Huntington's disease and implicate an interaction between pathology that is subcortical and cognitive function that is cortical.

Original languageEnglish (US)
Pages (from-to)94-104
Number of pages11
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number1
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health


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