To examine the relationship between cortical physiology and dementia in Huntington's disease rCBF during three different behavioural conditions, one of which emphasised prefrontal cognition, was determined by xenon-133 inhalation in 14 patients with Huntington's disease and in matched controls. Cortical rCBF was not reduced in Huntington's disease patients even while they manifested overt prefrontal-type cognitive deficits. Caudate atrophy on CT and rCBF were significantly correlated, but only during the prefrontal behaviour where the correlation was positive. These results suggets a qualification of the subcortical dementia concept as applied to Huntington's disease and implicate an interaction between pathology that is subcortical and cognitive function that is cortical.
|Original language||English (US)|
|Number of pages||11|
|Journal||Journal of Neurology Neurosurgery and Psychiatry|
|State||Published - 1988|
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health