Abstract
To examine the relationship between cortical physiology and dementia in Huntington's disease rCBF during three different behavioural conditions, one of which emphasised prefrontal cognition, was determined by xenon-133 inhalation in 14 patients with Huntington's disease and in matched controls. Cortical rCBF was not reduced in Huntington's disease patients even while they manifested overt prefrontal-type cognitive deficits. Caudate atrophy on CT and rCBF were significantly correlated, but only during the prefrontal behaviour where the correlation was positive. These results suggets a qualification of the subcortical dementia concept as applied to Huntington's disease and implicate an interaction between pathology that is subcortical and cognitive function that is cortical.
Original language | English (US) |
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Pages (from-to) | 94-104 |
Number of pages | 11 |
Journal | Journal of Neurology Neurosurgery and Psychiatry |
Volume | 51 |
Issue number | 1 |
DOIs | |
State | Published - 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Surgery
- Clinical Neurology
- Psychiatry and Mental health