Prefrontal cortex modulation during anticipation of working memory demands as revealed by magnetoencephalography

Mario Altamura, Terry E. Goldberg, Brita Elvevg, Tom Holroyd, Frederick W. Carver, Daniel R. Weinberger, Richard Coppola

Research output: Contribution to journalArticlepeer-review

Abstract

During the anticipation of task demands frontal control is involved in the assembly of stimulus-response mappings based on current goals. It is not clear whether prefrontal modulations occur in higher-order cortical regions, likely reflecting cognitive anticipation processes. The goal of this paper was to investigate prefrontal modulation during anticipation of upcoming working memory demands as revealed by magnetoencephalography (MEG). Twenty healthy volunteers underwent MEG while they performed a variation of the Sternberg Working Memory (WM) task. Beta band (14-30Hz) SAM (Synthetic Aperture Magnetometry) analysis was performed. During the preparatory periods there was an increase in beta power (event-related synchronization) in dorsolateral prefrontal cortex (DLPFC) bilaterally, left inferior prefrontal gyrus, left parietal, and temporal areas. Our results provide support for the hypothesis that, during preparatory states, the prefrontal cortex is important for biasing higher order brain regions that are going to be engaged in the upcoming task.

Original languageEnglish (US)
Article number840416
JournalInternational Journal of Biomedical Imaging
Volume2010
DOIs
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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