Prefilled devices for parenteral applications

Pablo Gurman, Albert Chi, Tiffany Hood, Micaela Reina, Yitzhak Rosen, Sebastian D'Hers, Noel Elman

Research output: Contribution to journalReview articlepeer-review

Abstract

Current parenteral administration of drugs suffers from several drawbacks including the requirement of healthcare personnel to administer the drug, the risk of needle stick injuries that may result in the transmission of blood borne pathogens, and patient discomfort. Prefilled devices have emerged as powerful tools to improve parenteral administration of drugs. There are a number of clinical conditions including treatment of endocrine diseases, neurological disorders, autoimmune diseases and emergency medicine where prefilled devices have made major improvements to patient care. Prefilled devices have become an important set of tools for the medical practitioner due to their ease of use and safety, cost effectiveness and patient convenience. This review provides a comprehensive summary of existing prefilled devices, their current clinical uses and corresponding regulatory processes.

Original languageEnglish (US)
Pages (from-to)205-223
Number of pages19
JournalExpert review of medical devices
Volume11
Issue number2
DOIs
StatePublished - Mar 2014
Externally publishedYes

Keywords

  • Acute conditions and chronic diseases
  • Ambulatory
  • Autoinjectors
  • Combination products
  • Drug delivery
  • Emergency medicine
  • Parenteral
  • Pen injectors
  • Prefilled devices
  • Therapeutic applications

ASJC Scopus subject areas

  • Surgery
  • Biomedical Engineering

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