Abstract
The most JH-proximal VH gene segments are used highly preferentially to form VHDJH rearrangements in pre-B-cell lines. This result demonstrates that the rate at which immunoglobulin V H gene segments recombine is influenced by their chromosomal organization, and that the initial repertoire ofVH genes expressed in pre-B cells is strikingly different from that seen in mature populations.
Original language | English (US) |
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Pages (from-to) | 727-733 |
Number of pages | 7 |
Journal | Nature |
Volume | 311 |
Issue number | 5988 |
DOIs | |
State | Published - Oct 25 1984 |
Externally published | Yes |
ASJC Scopus subject areas
- General