Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

George D. Yancopoulos, Stephen Desiderio, Michael Paskind, John F. Kearney, David Baltimore, Frederick W. Alt

Research output: Contribution to journalArticle

Abstract

The most JH-proximal VH gene segments are used highly preferentially to form VHDJH rearrangements in pre-B-cell lines. This result demonstrates that the rate at which immunoglobulin V H gene segments recombine is influenced by their chromosomal organization, and that the initial repertoire ofVH genes expressed in pre-B cells is strikingly different from that seen in mature populations.

Original languageEnglish (US)
Pages (from-to)727-733
Number of pages7
JournalNature
Volume311
Issue number5988
DOIs
StatePublished - 1984
Externally publishedYes

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B-Lymphoid Precursor Cells
Cell Line
Immunoglobulin Variable Region
Genes
Population

ASJC Scopus subject areas

  • General

Cite this

Yancopoulos, G. D., Desiderio, S., Paskind, M., Kearney, J. F., Baltimore, D., & Alt, F. W. (1984). Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature, 311(5988), 727-733. https://doi.org/10.1038/311727a0

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. / Yancopoulos, George D.; Desiderio, Stephen; Paskind, Michael; Kearney, John F.; Baltimore, David; Alt, Frederick W.

In: Nature, Vol. 311, No. 5988, 1984, p. 727-733.

Research output: Contribution to journalArticle

Yancopoulos, GD, Desiderio, S, Paskind, M, Kearney, JF, Baltimore, D & Alt, FW 1984, 'Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines', Nature, vol. 311, no. 5988, pp. 727-733. https://doi.org/10.1038/311727a0
Yancopoulos, George D. ; Desiderio, Stephen ; Paskind, Michael ; Kearney, John F. ; Baltimore, David ; Alt, Frederick W. / Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. In: Nature. 1984 ; Vol. 311, No. 5988. pp. 727-733.
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