Preferential alignment of birefringent tissue measured with polarization sensitive techniques

J. C. Ramella-Roman, T. Ruiz, P. Ghassemi, T. E. Travis, J. W. Shupp, J. Chue-Sang, Y. Bai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Assessing collagen alignment is of interest when evaluating a therapeutic strategy and evaluating its outcome in scar management. In this work we introduce a theoretical and experimental methodology for the quantification of collagen and birefringent media alignment based on polarized light transport. The technique relies on the fact that these materials exhibit directional anisotropy. A polarized Monte Carlo model and a spectro-polarimetric imaging system were devised to predict and measure the impact of birefringence on an impinging polarized light beam. Experiments conducted on birefringent phantoms, and biological samples consisting of highly packed parallel birefringent fibers, showed a good agreement with the analytical results.

Original languageEnglish (US)
Title of host publicationPhotonic Therapeutics and Diagnostics XI
PublisherSPIE
Volume9303
ISBN (Print)9781628413939
DOIs
StatePublished - 2015
Externally publishedYes
EventPhotonic Therapeutics and Diagnostics XI - San Francisco, United States
Duration: Feb 7 2015Feb 8 2015

Other

OtherPhotonic Therapeutics and Diagnostics XI
CountryUnited States
CitySan Francisco
Period2/7/152/8/15

Keywords

  • Collagen
  • Directional Anisotropy
  • Polarimetry

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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