Preemptive retransplantation for BK virus nephropathy: Successful outcome despite active viremia

K. L. Womer, H. U. Meier-Kriesche, P. R. Patton, K. Dibadj, C. M. Bucci, D. Foley, S. Fujita, B. P. Croker, R. J. Howard, T. R. Srinivas, B. Kaplan

Research output: Contribution to journalArticle

Abstract

BK virus nephropathy (BKVN) is now recognized as a major cause of renal allograft loss. Recent reports suggest that retransplantation in patients with graft loss due to BKVN is safe after return to dialysis. Since early transplantation is associated with improved outcomes, it would be advantageous if this procedure could be performed prior to ultimate graft loss. However, little data are available regarding the safety of this approach during active viremia. In this report, we describe successful preemptive retransplantation with simultaneous allograft nephrectomy in two patients with active BKVN and viremia at the time of surgery. With 21- and 12-month follow-up, respectively, both patients have stable allograft function and no evidence for active viral replication. We conclude that preemptive retransplantation can be considered in patients with failing allografts due to BKVN.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalAmerican Journal of Transplantation
Volume6
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • BK
  • Chronic allograft nephropathy
  • Kidney transplant
  • Polyomavirus nephropathy
  • Retransplantation
  • Viremia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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  • Cite this

    Womer, K. L., Meier-Kriesche, H. U., Patton, P. R., Dibadj, K., Bucci, C. M., Foley, D., Fujita, S., Croker, B. P., Howard, R. J., Srinivas, T. R., & Kaplan, B. (2006). Preemptive retransplantation for BK virus nephropathy: Successful outcome despite active viremia. American Journal of Transplantation, 6(1), 209-213. https://doi.org/10.1111/j.1600-6143.2005.01137.x