Abstract
Several neuropsychiatric illness, including depression and Alzheimer's disease, are reported to be characterized by hypercortisolemia and by reduced levels of cerebrospinal fluid somatostatin-like immunoreactivity (CSF-SLI). To investigate a possible causal linkage between these abnormalities we administered prednisone, 80 mg orally per day for 5 days, to 9 healthy volunteers. We observed significant prednisone-induced reductions in CSF-SLI. Moreover, the magnitude of these reductions was inversely related to the magnitude of prednisone-induced reductions in plasma ACTH levels, suggesting a functional interaction between circulating corticosteroids, central somatostatin and pituitary ACTH release.
Original language | English (US) |
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Pages (from-to) | 1929-1933 |
Number of pages | 5 |
Journal | Life Sciences |
Volume | 41 |
Issue number | 16 |
DOIs | |
State | Published - Oct 19 1987 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology