Predictors of the isolated hepatitis B core antibody pattern in HIV-infected and-uninfected men in the multicenter AIDS cohort study

Mallory D. Witt, Roger J. Lewis, Gunter Rieg, Eric Carl Seaberg, Charles R. Rinaldo, Chloe L Thio

Research output: Contribution to journalArticle

Abstract

Background. The significance of hepatitis B core antibody (anti-HBc) without hepatitis B surface antigen (HBsAg) or hepatitis B surface antibody (anti-HBs) is unclear.Methods. This cohort study included men enrolled in the Multicenter AIDS Cohort to determine clinical and laboratory predictors of isolated anti-HBc.Results. A total of 2286 subjects (51% human immunodeficiency virus [HIV]-infected) were followed over 3.9 years. Overall, 16.9% (387) had at least 1 visit with isolated anti-HBc. The isolated anti-HBc pattern was stable 84% of the time, and transitioned to or from a pattern of past infection (anti-HBc and anti-HBs). Isolated anti-HBc was associated with HIV infection (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.73-2.79) and hepatitis C virus (HCV; OR, 4.21; 95% CI; 2.99-5.91). The HCV association was stronger for chronic HCV infection (OR, 6.76; 95% CI, 5.08-8.99) than for cleared HCV (OR, 3.03; 95% CI, 1.83-5.03). HIV infection, chronic HCV, and cleared HCV infection all remained associated with isolated anti-HBc in multivariable models (OR, 1.74; 95% CI, 1.33-2.29; OR, 6.24; 95% CI, 4.62-8.42; and OR, 2.77; 95% CI, 1.65-4.66, respectively). Among HIV-infected subjects, highly active antiretroviral therapy was negatively associated (OR, 0.79; 95% CI,. 66-.95) with isolated anti-HBc. Conclusions. Isolated anti-HBc is associated with HIV and HCV coinfection, especially active HCV replication, and most commonly occurs as a transition to or from the pattern of natural immunity (anti-HBc and anti-HBs). The isolated anti-HBc pattern likely represents resolved HBV infection with low or undetected anti-HBs.

Original languageEnglish (US)
Pages (from-to)606-612
Number of pages7
JournalClinical Infectious Diseases
Volume56
Issue number4
DOIs
StatePublished - Feb 15 2013

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Hepatitis B Antibodies
Acquired Immunodeficiency Syndrome
Cohort Studies
Odds Ratio
HIV
Confidence Intervals
Virus Diseases
Infection
Highly Active Antiretroviral Therapy
Hepatitis B Surface Antigens
Coinfection
Innate Immunity
Hepacivirus

Keywords

  • hepatitis B core antibody
  • hepatitis C
  • highly active antiretroviral therapy
  • human immunodeficiency virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Predictors of the isolated hepatitis B core antibody pattern in HIV-infected and-uninfected men in the multicenter AIDS cohort study. / Witt, Mallory D.; Lewis, Roger J.; Rieg, Gunter; Seaberg, Eric Carl; Rinaldo, Charles R.; Thio, Chloe L.

In: Clinical Infectious Diseases, Vol. 56, No. 4, 15.02.2013, p. 606-612.

Research output: Contribution to journalArticle

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title = "Predictors of the isolated hepatitis B core antibody pattern in HIV-infected and-uninfected men in the multicenter AIDS cohort study",
abstract = "Background. The significance of hepatitis B core antibody (anti-HBc) without hepatitis B surface antigen (HBsAg) or hepatitis B surface antibody (anti-HBs) is unclear.Methods. This cohort study included men enrolled in the Multicenter AIDS Cohort to determine clinical and laboratory predictors of isolated anti-HBc.Results. A total of 2286 subjects (51{\%} human immunodeficiency virus [HIV]-infected) were followed over 3.9 years. Overall, 16.9{\%} (387) had at least 1 visit with isolated anti-HBc. The isolated anti-HBc pattern was stable 84{\%} of the time, and transitioned to or from a pattern of past infection (anti-HBc and anti-HBs). Isolated anti-HBc was associated with HIV infection (odds ratio [OR], 2.19; 95{\%} confidence interval [CI], 1.73-2.79) and hepatitis C virus (HCV; OR, 4.21; 95{\%} CI; 2.99-5.91). The HCV association was stronger for chronic HCV infection (OR, 6.76; 95{\%} CI, 5.08-8.99) than for cleared HCV (OR, 3.03; 95{\%} CI, 1.83-5.03). HIV infection, chronic HCV, and cleared HCV infection all remained associated with isolated anti-HBc in multivariable models (OR, 1.74; 95{\%} CI, 1.33-2.29; OR, 6.24; 95{\%} CI, 4.62-8.42; and OR, 2.77; 95{\%} CI, 1.65-4.66, respectively). Among HIV-infected subjects, highly active antiretroviral therapy was negatively associated (OR, 0.79; 95{\%} CI,. 66-.95) with isolated anti-HBc. Conclusions. Isolated anti-HBc is associated with HIV and HCV coinfection, especially active HCV replication, and most commonly occurs as a transition to or from the pattern of natural immunity (anti-HBc and anti-HBs). The isolated anti-HBc pattern likely represents resolved HBV infection with low or undetected anti-HBs.",
keywords = "hepatitis B core antibody, hepatitis C, highly active antiretroviral therapy, human immunodeficiency virus",
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T1 - Predictors of the isolated hepatitis B core antibody pattern in HIV-infected and-uninfected men in the multicenter AIDS cohort study

AU - Witt, Mallory D.

AU - Lewis, Roger J.

AU - Rieg, Gunter

AU - Seaberg, Eric Carl

AU - Rinaldo, Charles R.

AU - Thio, Chloe L

PY - 2013/2/15

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N2 - Background. The significance of hepatitis B core antibody (anti-HBc) without hepatitis B surface antigen (HBsAg) or hepatitis B surface antibody (anti-HBs) is unclear.Methods. This cohort study included men enrolled in the Multicenter AIDS Cohort to determine clinical and laboratory predictors of isolated anti-HBc.Results. A total of 2286 subjects (51% human immunodeficiency virus [HIV]-infected) were followed over 3.9 years. Overall, 16.9% (387) had at least 1 visit with isolated anti-HBc. The isolated anti-HBc pattern was stable 84% of the time, and transitioned to or from a pattern of past infection (anti-HBc and anti-HBs). Isolated anti-HBc was associated with HIV infection (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.73-2.79) and hepatitis C virus (HCV; OR, 4.21; 95% CI; 2.99-5.91). The HCV association was stronger for chronic HCV infection (OR, 6.76; 95% CI, 5.08-8.99) than for cleared HCV (OR, 3.03; 95% CI, 1.83-5.03). HIV infection, chronic HCV, and cleared HCV infection all remained associated with isolated anti-HBc in multivariable models (OR, 1.74; 95% CI, 1.33-2.29; OR, 6.24; 95% CI, 4.62-8.42; and OR, 2.77; 95% CI, 1.65-4.66, respectively). Among HIV-infected subjects, highly active antiretroviral therapy was negatively associated (OR, 0.79; 95% CI,. 66-.95) with isolated anti-HBc. Conclusions. Isolated anti-HBc is associated with HIV and HCV coinfection, especially active HCV replication, and most commonly occurs as a transition to or from the pattern of natural immunity (anti-HBc and anti-HBs). The isolated anti-HBc pattern likely represents resolved HBV infection with low or undetected anti-HBs.

AB - Background. The significance of hepatitis B core antibody (anti-HBc) without hepatitis B surface antigen (HBsAg) or hepatitis B surface antibody (anti-HBs) is unclear.Methods. This cohort study included men enrolled in the Multicenter AIDS Cohort to determine clinical and laboratory predictors of isolated anti-HBc.Results. A total of 2286 subjects (51% human immunodeficiency virus [HIV]-infected) were followed over 3.9 years. Overall, 16.9% (387) had at least 1 visit with isolated anti-HBc. The isolated anti-HBc pattern was stable 84% of the time, and transitioned to or from a pattern of past infection (anti-HBc and anti-HBs). Isolated anti-HBc was associated with HIV infection (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.73-2.79) and hepatitis C virus (HCV; OR, 4.21; 95% CI; 2.99-5.91). The HCV association was stronger for chronic HCV infection (OR, 6.76; 95% CI, 5.08-8.99) than for cleared HCV (OR, 3.03; 95% CI, 1.83-5.03). HIV infection, chronic HCV, and cleared HCV infection all remained associated with isolated anti-HBc in multivariable models (OR, 1.74; 95% CI, 1.33-2.29; OR, 6.24; 95% CI, 4.62-8.42; and OR, 2.77; 95% CI, 1.65-4.66, respectively). Among HIV-infected subjects, highly active antiretroviral therapy was negatively associated (OR, 0.79; 95% CI,. 66-.95) with isolated anti-HBc. Conclusions. Isolated anti-HBc is associated with HIV and HCV coinfection, especially active HCV replication, and most commonly occurs as a transition to or from the pattern of natural immunity (anti-HBc and anti-HBs). The isolated anti-HBc pattern likely represents resolved HBV infection with low or undetected anti-HBs.

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KW - hepatitis C

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KW - human immunodeficiency virus

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