Predictors of subjective memory complaint in cognitively normal relatives of patients with Alzheimer's disease

David H. Tsai, Robert C. Green, Kelly Benke, Rebecca A. Silliman, Lindsay A. Farrer

Research output: Contribution to journalArticlepeer-review

Abstract

The authors utilized a family-based, case-control study to identify factors predicting subjective memory complaint in relatives of Alzheimer's disease patients. The authors ascertained 1,499 cognitively healthy relatives of Alzheimer's disease patients at 15 centers, who contributed demographic and medical information, including self-assessment of memory. First-degree relatives of Alzheimer's disease patients reported subjective memory complaint more than spouses of Alzheimer's disease patients. Relatives with past depression symptoms endorsed subjective memory complaint more than those without such history. Clinicians counseling family members of Alzheimer's disease patients who express subjective memory complaint should first evaluate cognition. If cognition is intact, depression should be considered.

Original languageEnglish (US)
Pages (from-to)384-388
Number of pages5
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume18
Issue number3
DOIs
StatePublished - Aug 2006
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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