Predictors of statin compliance after switching from branded to generic agents among managed-care beneficiaries

Robert J. Romanelli, Jodi Segal

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To identify patient demographics and characteristics associated with compliance to statin therapy after switching from branded to generic agents DESIGN: Retrospective cohort study using electronic health records and pharmacy claims data from Sutter Health's ambulatory-care medical network PATIENTS: Managed-care beneficiaries, 18 years of age, who were switched from branded to generic statins between 1 January 2003 and 31 December 2012 MAIN MEASURES: Compliance was calculated as days of therapy dispensed divided by days from first to last generic prescription fill over 6 months, and was defined as a medication possession ratio 0.80. We used multivariable logistic regression to assess factors associated with compliance. Adjusted ORs and 95 % CI were generated. KEY RESULTS: We identified 5,156 patients who were switched from branded to generic statins; 73 % of patients were compliant in the 6 months after switching. After statistical adjustment, higher compliance was associated with each 10-year increase in age (OR: 1.13; 95 % CI: 1.07, 1.19; p∈

Original languageEnglish (US)
Pages (from-to)1372-1378
Number of pages7
JournalJournal of General Internal Medicine
Volume29
Issue number10
DOIs
StatePublished - Oct 1 2014

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Managed Care Programs
Compliance
Electronic Health Records
Ambulatory Care
Prescriptions
Cohort Studies
Retrospective Studies
Logistic Models
Demography
Delivery of Health Care
Therapeutics

Keywords

  • drug interchange
  • generics
  • medication compliance
  • statins
  • switching

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

Predictors of statin compliance after switching from branded to generic agents among managed-care beneficiaries. / Romanelli, Robert J.; Segal, Jodi.

In: Journal of General Internal Medicine, Vol. 29, No. 10, 01.10.2014, p. 1372-1378.

Research output: Contribution to journalArticle

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