Predictors of Retest Effects in a Longitudinal Study of Cognitive Aging in a Diverse Community-Based Sample

Alden L. Gross, Andreana Benitez, Regina Shih, Katherine J. Bangen, M. Maria M. Glymour, Bonnie Sachs, Shannon Sisco, Jeannine Skinner, Brooke C. Schneider, Jennifer J. Manly

Research output: Contribution to journalArticle

Abstract

Better performance due to repeated testing can bias long-term trajectories of cognitive aging and correlates of change. We examined whether retest effects differ as a function of individual differences pertinent to cognitive aging: race/ethnicity, age, sex, language, years of education, literacy, and dementia risk factors including apolipoprotein E ε4 status, baseline cognitive performance, and cardiovascular risk. We used data from the Washington Heights-Inwood Columbia Aging Project, a community-based cohort of older adults (n = 4073). We modeled cognitive change and retest effects in summary factors for general cognitive performance, memory, executive functioning, and language using multilevel models. Retest effects were parameterized in two ways, as improvement between the first and subsequent testings, and as the square root of the number of prior testings. We evaluated whether the retest effect differed by individual characteristics. The mean retest effect for general cognitive performance was 0.60 standard deviations (95% confidence interval [0.46, 0.74]), and was similar for memory, executive functioning, and language. Retest effects were greater for participants in the lowest quartile of cognitive performance (many of whom met criteria for dementia based on a study algorithm), consistent with regression to the mean. Retest did not differ by other characteristics. Retest effects are large in this community-based sample, but do not vary by demographic or dementia-related characteristics. Differential retest effects may not limit the generalizability of inferences across different groups in longitudinal research. (JINS, 2015, 21, 506-518).

Original languageEnglish (US)
Pages (from-to)506-518
Number of pages13
JournalJournal of the International Neuropsychological Society
Volume21
Issue number7
DOIs
StatePublished - Jun 15 2015

Keywords

  • Gerontology
  • Individual differences
  • Neuropsychological testing
  • Older adults
  • Practice effect
  • Retest effect

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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    Gross, A. L., Benitez, A., Shih, R., Bangen, K. J., Glymour, M. M. M., Sachs, B., Sisco, S., Skinner, J., Schneider, B. C., & Manly, J. J. (2015). Predictors of Retest Effects in a Longitudinal Study of Cognitive Aging in a Diverse Community-Based Sample. Journal of the International Neuropsychological Society, 21(7), 506-518. https://doi.org/10.1017/S1355617715000508