Predictors of repeat Chlamydia trachomatis infections diagnosed by DNA amplification testing among inner city females

G. R. Burstein, J. M. Zenilman, C. A. Gaydos, M. Diener-West, M. R. Howell, W. Brathwaite, T. C. Quinn

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To describe the epidemiology of prevalent and incident chlamydia infection in order to assess the appropriate interval for chlamydia screening; and to identify risk factors predictive of infection and repeat infections. Design: Prospective longitudinal study of a consecutive sample of 3860 sexually active females aged 12-60 years tested for C trachomatis by polymerase chain reaction in Baltimore City clinics during 11, 904 patient visits over a 33 month period. Results: Chlamydia prevalence, incidence, and frequency to diagnosis of infection varied by age. Among 2073 females <25 years, chlamydia infection was found in 31.2%. The median times to first and repeat incident infections were 7.0 months and 7.6 months, respectively. Among 1787 females ≥25 years, chlamydia infection was found in 9.6%. Median times to first and repeat incident infections were 13.8 months and 11.0 months, respectively. Age <25 years yielded the highest risk of infection. Conclusions: Since a high burden of chlamydia was found among mostly asymptomatic females <25 years in a spectrum of clinical settings, we recommend chlamydia screening for all sexually active females <25 years at least twice yearly.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalSexually transmitted infections
Volume77
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Adolescents
  • Chlamydia
  • Sexually transmitted diseases

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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