TY - JOUR
T1 - Predictors of progression to severe Alzheimer's disease in an incidence sample
AU - Rabins, Peter V.
AU - Schwartz, Sarah
AU - Black, Betty S.
AU - Corcoran, Christopher
AU - Fauth, Elizabeth
AU - Mielke, Michele
AU - Christensen, Jessica
AU - Lyketsos, Constantine
AU - Tschanz, Joann
N1 - Funding Information:
This research was supported by the following grants from the National Institute on Aging : R01AG21136 , R01AG11380 , and R01AG18712 .
Funding Information:
P.V.R. is supported by NIMH, NIA, Associated Jewish Federation of Baltimore; Legal testimony for Janssen Pharmaceutica . C.L. is supported by (research or CME ), NIMH, NIA, Associated Jewish Federation of Baltimore, Weinberg Foundation, Forest, Glaxo-Smith-Kline, Eisai, Pfizer, Astra-Zeneca, Lilly, Ortho-McNeil, Bristol-Myers, Novartis .
PY - 2013/3
Y1 - 2013/3
N2 - Background: Little is known about factors influencing time to severe Alzheimer's disease (AD). Methods: Incident cases of AD in the Cache County Memory Study were identified. Severe AD was defined as Mini-Mental State Examination score of ≤10 or Clinical Dementia Rating Scale score of 3; cases with either Mini-Mental State Examination score of ≥16 or Clinical Dementia Rating <2 were not categorized as severe AD. Kaplan-Meier, log-rank tests, and Cox analyses were used to identify demographic, clinical, and genetic correlates of time to progression to severe AD. Results: Sixty-eight of 335 cases of incident AD developed severe dementia. In bivariate analyses, female gender, less than high school education, at least one clinically significant Neuropsychiatric Inventory domain at baseline, and the youngest and oldest ages exhibited shorter time to severe AD. In competing risk analysis, subjects with mild or at least one clinically significant Neuropsychiatric Inventory domain score, and subjects with worse health were more likely to progress to severe dementia or death. Conclusions: Demographic and clinical variables predict progression to severe AD. Further study should examine whether these relationships are causal or correlational.
AB - Background: Little is known about factors influencing time to severe Alzheimer's disease (AD). Methods: Incident cases of AD in the Cache County Memory Study were identified. Severe AD was defined as Mini-Mental State Examination score of ≤10 or Clinical Dementia Rating Scale score of 3; cases with either Mini-Mental State Examination score of ≥16 or Clinical Dementia Rating <2 were not categorized as severe AD. Kaplan-Meier, log-rank tests, and Cox analyses were used to identify demographic, clinical, and genetic correlates of time to progression to severe AD. Results: Sixty-eight of 335 cases of incident AD developed severe dementia. In bivariate analyses, female gender, less than high school education, at least one clinically significant Neuropsychiatric Inventory domain at baseline, and the youngest and oldest ages exhibited shorter time to severe AD. In competing risk analysis, subjects with mild or at least one clinically significant Neuropsychiatric Inventory domain score, and subjects with worse health were more likely to progress to severe dementia or death. Conclusions: Demographic and clinical variables predict progression to severe AD. Further study should examine whether these relationships are causal or correlational.
KW - Incident dementia
KW - Rate of decline
KW - Severe AD
KW - Severe dementia
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U2 - 10.1016/j.jalz.2012.01.003
DO - 10.1016/j.jalz.2012.01.003
M3 - Article
C2 - 23123228
AN - SCOPUS:84875370409
SN - 1552-5260
VL - 9
SP - 204
EP - 207
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 2
ER -