Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children

Kamau O. Peters, D' Ann L Williams, Salahadin Abubaker, Jean Curtin-Brosnan, Meredith McCormack, Roger Peng, Patrick N Breysse, Elizabeth C. Matsui, Nadia Hansel, Gregory B Diette, Paul Timothy Strickland

Research output: Contribution to journalArticle


Polycyclic aromatic hydrocarbons (PAHs), the by-products of incomplete combustion of organic materials, are commonly found on particulate matter (PM) and have been associated with the development of asthma and asthma exacerbation in urban populations. We examined time spent in the home and outdoors as predictors of exposures to airborne PAHs and measured urinary 1-hydroxypyrene-glucuronide (1-OHPG) as internal dose of PAHs in 118 children aged 5–12 years from Baltimore, MD. During weeklong periods (Saturday–Saturday) in each of four seasons: daily activities were assessed using questionnaires, indoor air nicotine and PM concentrations were monitored, and urine specimens were collected on Tuesday (day 3) and Saturday (day 7) for measurement of 1-OHPG. Time spent in non-smoking homes was associated with significantly decreased 1-OHPG concentration in urine (β=−0.045, 95% CI (−0.076, −0.013)), and secondhand smoke (SHS) exposures modified these associations, with higher urinary 1-OHPG concentrations in children spending time in smoking homes than non-smoking homes (P-value for interaction=0.012). Time spent outdoors was associated with increased urinary 1-OHPG concentrations (β=0.097, 95% CI (0.037, 0.157)) in boys only. Our results suggest that SHS and ambient (outdoor) air pollution contribute to internal dose of PAHs in inner city children.Journal of Exposure Science and Environmental Epidemiology advance online publication, 14 December 2016; doi:10.1038/jes.2016.57.

Original languageEnglish (US)
JournalJournal of Exposure Science and Environmental Epidemiology
StateAccepted/In press - Dec 14 2016

ASJC Scopus subject areas

  • Epidemiology
  • Toxicology
  • Pollution
  • Public Health, Environmental and Occupational Health

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