Predictors of outcome in LAAM, buprenorphine, and methadone treatment for opioid dependence

Lisa A. Marsch, Mary Ann Chutuape Stephens, Timothy Mudric, Eric C. Strain, George E. Bigelow, Rolley E. Johnson

Research output: Contribution to journalArticlepeer-review

Abstract

This study examined (1) predictors of treatment outcome for opioid-dependent participants in a single-site controlled trial comparing methadone, buprenorphine, and LAAM treatments and (2) the extent to which various subpopulations of patients may have more successful outcomes with each medication. The relationships between patient demographics, drug use history, and psychological status and outcome measures of treatment retention, opiate use, and cocaine use were assessed. We believe this study to be the first to demonstrate that predictors of treatment success appear to be largely similar in LAAM, buprenorphine, and methadone treatment for opioid dependence. We did not find any factors that would strongly guide selection of one medication over others.

Original languageEnglish (US)
Pages (from-to)293-302
Number of pages10
JournalExperimental and clinical psychopharmacology
Volume13
Issue number4
DOIs
StatePublished - Nov 2005

Keywords

  • Buprenorphine
  • LAAM
  • Methadone
  • Opioid
  • Treatment

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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