Predictors of mortality among injecting and non-injecting HIV-negative drug users in northern Thailand

Vu Minh Quan, Tasanai Vongchak, Jaroon Jittiwutikarn, Surinda Kawichai, Namtip Srirak, Kanokporn Wiboonnatakul, Myat Htoo Razak, Vinai Suriyanon, David D Celentano

Research output: Contribution to journalArticle

Abstract

Aims: To estimate mortality rates among HIV-negative injecting drug users (IDUs) and non-injecting drug users (non-IDUs), and to assess predictors for mortality among the IDUs. Design: Prospective cohort study in northern Thailand with 2-year follow-up. Setting: IDUs and non-IDUs who were admitted for detoxification treatment for opiate or amphetamine dependence in a regional drug treatment center were screened. After discharge, HIV-negative individuals were followed-up in the community. Participants: A total of 821 HIV-negative drug users [346 IDUs (42%) and 475 non-IDUs, median age = 32; 51% were ethnic minorities]. Measurements: All-cause mortality. Findings: There were 33 deaths over 1360 person-years of follow-up. The all-cause mortality rate was 39 per 1000 person-years among IDUs [standardized mortality ratio (SMR) = 13.9], and was 14 per 1000 person-years among non-IDUs (SMR = 4.4). Among male IDUs, the hazards for all-cause deaths were ethnic minority status [adjusted hazard ratio (HR) = 2.9, 95% CI = 1.2-7.2], incident HIV infection (HR = 2.8, 95% CI = 1.1-7.7) and longer duration of drug injection (HR = 1.07, 95% CI = 1.01-1.14). Conclusions: The mortality among IDUs is high. Being from an ethnic minority, recent HIV acquisition, and a greater number of years of drug injection are predictors of mortality among the IDUs in this region.

Original languageEnglish (US)
Pages (from-to)441-446
Number of pages6
JournalAddiction
Volume102
Issue number3
DOIs
StatePublished - Mar 2007

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Thailand
Drug Users
HIV
Mortality
Amphetamine-Related Disorders
Substance Abuse Treatment Centers
Opioid-Related Disorders
Injections
Pharmaceutical Preparations
HIV Infections
Cause of Death
Cohort Studies
Prospective Studies

Keywords

  • HIV
  • Incidence
  • Mortality
  • Substance abuse
  • Thailand

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Predictors of mortality among injecting and non-injecting HIV-negative drug users in northern Thailand. / Quan, Vu Minh; Vongchak, Tasanai; Jittiwutikarn, Jaroon; Kawichai, Surinda; Srirak, Namtip; Wiboonnatakul, Kanokporn; Razak, Myat Htoo; Suriyanon, Vinai; Celentano, David D.

In: Addiction, Vol. 102, No. 3, 03.2007, p. 441-446.

Research output: Contribution to journalArticle

Quan, VM, Vongchak, T, Jittiwutikarn, J, Kawichai, S, Srirak, N, Wiboonnatakul, K, Razak, MH, Suriyanon, V & Celentano, DD 2007, 'Predictors of mortality among injecting and non-injecting HIV-negative drug users in northern Thailand', Addiction, vol. 102, no. 3, pp. 441-446. https://doi.org/10.1111/j.1360-0443.2006.01709.x
Quan, Vu Minh ; Vongchak, Tasanai ; Jittiwutikarn, Jaroon ; Kawichai, Surinda ; Srirak, Namtip ; Wiboonnatakul, Kanokporn ; Razak, Myat Htoo ; Suriyanon, Vinai ; Celentano, David D. / Predictors of mortality among injecting and non-injecting HIV-negative drug users in northern Thailand. In: Addiction. 2007 ; Vol. 102, No. 3. pp. 441-446.
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abstract = "Aims: To estimate mortality rates among HIV-negative injecting drug users (IDUs) and non-injecting drug users (non-IDUs), and to assess predictors for mortality among the IDUs. Design: Prospective cohort study in northern Thailand with 2-year follow-up. Setting: IDUs and non-IDUs who were admitted for detoxification treatment for opiate or amphetamine dependence in a regional drug treatment center were screened. After discharge, HIV-negative individuals were followed-up in the community. Participants: A total of 821 HIV-negative drug users [346 IDUs (42{\%}) and 475 non-IDUs, median age = 32; 51{\%} were ethnic minorities]. Measurements: All-cause mortality. Findings: There were 33 deaths over 1360 person-years of follow-up. The all-cause mortality rate was 39 per 1000 person-years among IDUs [standardized mortality ratio (SMR) = 13.9], and was 14 per 1000 person-years among non-IDUs (SMR = 4.4). Among male IDUs, the hazards for all-cause deaths were ethnic minority status [adjusted hazard ratio (HR) = 2.9, 95{\%} CI = 1.2-7.2], incident HIV infection (HR = 2.8, 95{\%} CI = 1.1-7.7) and longer duration of drug injection (HR = 1.07, 95{\%} CI = 1.01-1.14). Conclusions: The mortality among IDUs is high. Being from an ethnic minority, recent HIV acquisition, and a greater number of years of drug injection are predictors of mortality among the IDUs in this region.",
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T1 - Predictors of mortality among injecting and non-injecting HIV-negative drug users in northern Thailand

AU - Quan, Vu Minh

AU - Vongchak, Tasanai

AU - Jittiwutikarn, Jaroon

AU - Kawichai, Surinda

AU - Srirak, Namtip

AU - Wiboonnatakul, Kanokporn

AU - Razak, Myat Htoo

AU - Suriyanon, Vinai

AU - Celentano, David D

PY - 2007/3

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N2 - Aims: To estimate mortality rates among HIV-negative injecting drug users (IDUs) and non-injecting drug users (non-IDUs), and to assess predictors for mortality among the IDUs. Design: Prospective cohort study in northern Thailand with 2-year follow-up. Setting: IDUs and non-IDUs who were admitted for detoxification treatment for opiate or amphetamine dependence in a regional drug treatment center were screened. After discharge, HIV-negative individuals were followed-up in the community. Participants: A total of 821 HIV-negative drug users [346 IDUs (42%) and 475 non-IDUs, median age = 32; 51% were ethnic minorities]. Measurements: All-cause mortality. Findings: There were 33 deaths over 1360 person-years of follow-up. The all-cause mortality rate was 39 per 1000 person-years among IDUs [standardized mortality ratio (SMR) = 13.9], and was 14 per 1000 person-years among non-IDUs (SMR = 4.4). Among male IDUs, the hazards for all-cause deaths were ethnic minority status [adjusted hazard ratio (HR) = 2.9, 95% CI = 1.2-7.2], incident HIV infection (HR = 2.8, 95% CI = 1.1-7.7) and longer duration of drug injection (HR = 1.07, 95% CI = 1.01-1.14). Conclusions: The mortality among IDUs is high. Being from an ethnic minority, recent HIV acquisition, and a greater number of years of drug injection are predictors of mortality among the IDUs in this region.

AB - Aims: To estimate mortality rates among HIV-negative injecting drug users (IDUs) and non-injecting drug users (non-IDUs), and to assess predictors for mortality among the IDUs. Design: Prospective cohort study in northern Thailand with 2-year follow-up. Setting: IDUs and non-IDUs who were admitted for detoxification treatment for opiate or amphetamine dependence in a regional drug treatment center were screened. After discharge, HIV-negative individuals were followed-up in the community. Participants: A total of 821 HIV-negative drug users [346 IDUs (42%) and 475 non-IDUs, median age = 32; 51% were ethnic minorities]. Measurements: All-cause mortality. Findings: There were 33 deaths over 1360 person-years of follow-up. The all-cause mortality rate was 39 per 1000 person-years among IDUs [standardized mortality ratio (SMR) = 13.9], and was 14 per 1000 person-years among non-IDUs (SMR = 4.4). Among male IDUs, the hazards for all-cause deaths were ethnic minority status [adjusted hazard ratio (HR) = 2.9, 95% CI = 1.2-7.2], incident HIV infection (HR = 2.8, 95% CI = 1.1-7.7) and longer duration of drug injection (HR = 1.07, 95% CI = 1.01-1.14). Conclusions: The mortality among IDUs is high. Being from an ethnic minority, recent HIV acquisition, and a greater number of years of drug injection are predictors of mortality among the IDUs in this region.

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