TY - JOUR
T1 - Predictors of low-density lipoprotein particle size in a high-risk African-American population
AU - Benton, Jeana L.
AU - Blumenthal, Roger S.
AU - Becker, Diane M.
AU - Yanek, Lisa R.
AU - Moy, Taryn F.
AU - Post, Wendy
PY - 2005/6/1
Y1 - 2005/6/1
N2 - A predominance of small, dense, low-density lipoprotein particles (pattern B) has been associated with increased cardiovascular risk independent of absolute cholesterol levels in primarily white populations. Because of the putative association of pattern B with increased risk, some investigators have proposed that routine measurement of low-density lipoprotein particle size may be beneficial for cardiovascular risk assessment. Because no studies have specifically examined this possibility in African-Americans, it remains unclear whether measurement of low-density lipoprotein particle size adds information beyond that of traditional lipid risk factors. We compared standard lipid profile measurements with extended measurements concurrently in an apparently healthy, high-risk population of African-American siblings of patients who had premature cardiovascular disease. We determined the extent to which patients who had pattern B would be identifiable from the usual lipid profile. A high triglyceride level alone was a strong independent correlate of pattern B. In subjects whose triglyceride level was ≥150 mg/dl, 67% had pattern B, whereas only 17% of subjects whose triglyceride level was <150 mg/dl had pattern B. The area under the receiver-operating characteristic curve was 0.77. Our data suggest that the standard lipid profile, primarily fasting triglyceride measurement, appears to be a useful surrogate for direct measurement of particle size in a high-risk African-American population.
AB - A predominance of small, dense, low-density lipoprotein particles (pattern B) has been associated with increased cardiovascular risk independent of absolute cholesterol levels in primarily white populations. Because of the putative association of pattern B with increased risk, some investigators have proposed that routine measurement of low-density lipoprotein particle size may be beneficial for cardiovascular risk assessment. Because no studies have specifically examined this possibility in African-Americans, it remains unclear whether measurement of low-density lipoprotein particle size adds information beyond that of traditional lipid risk factors. We compared standard lipid profile measurements with extended measurements concurrently in an apparently healthy, high-risk population of African-American siblings of patients who had premature cardiovascular disease. We determined the extent to which patients who had pattern B would be identifiable from the usual lipid profile. A high triglyceride level alone was a strong independent correlate of pattern B. In subjects whose triglyceride level was ≥150 mg/dl, 67% had pattern B, whereas only 17% of subjects whose triglyceride level was <150 mg/dl had pattern B. The area under the receiver-operating characteristic curve was 0.77. Our data suggest that the standard lipid profile, primarily fasting triglyceride measurement, appears to be a useful surrogate for direct measurement of particle size in a high-risk African-American population.
UR - http://www.scopus.com/inward/record.url?scp=19344371369&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19344371369&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2005.01.075
DO - 10.1016/j.amjcard.2005.01.075
M3 - Article
C2 - 15904636
AN - SCOPUS:19344371369
SN - 0002-9149
VL - 95
SP - 1320
EP - 1323
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 11
ER -