Predictors of long-term outcomes in asymptomatic patients with severe aortic stenosis and preserved left ventricular systolic function undergoing exercise echocardiography

Ahmad Masri, Andrew L. Goodman, Tyler Barr, Richard A. Grimm, Joseph F. Sabik, A. Marc Gillinov, L. Leonardo Rodriguez, Lars G. Svensson, Brian P. Griffin, Milind Y. Desai

Research output: Contribution to journalArticlepeer-review

Abstract

Background - In asymptomatic patients with severe aortic stenosis and preserved left ventricular ejection fraction, we sought to assess incremental prognostic utility of exercise stress echocardiography. Methods and Results - We studied 533 such patients (age, 66±13 years; 78% men; 31% with coronary artery disease) who underwent exercise stress echocardiography between 2001 and 2012. Clinical, echocardiographic, and exercise variables (metabolic equivalents [METs], % of age-sex-predicted METs and heart rate recovery at first minute post exercise) were recorded. The end point was all-cause mortality. The Society of Thoracic Surgeons score, left ventricular ejection fraction, mean resting aortic valve (AV) gradient, indexed AV area, METs, and heart rate recovery were 2.9±3%, 58±4%, 35±11 mm Hg, 0.47±0.1 cm2/m2, 7.8±3, and 26±12 bpm, respectively. Only 50% achieved >100%, whereas 26% achieved

Original languageEnglish (US)
JournalCirculation: Cardiovascular Imaging
Volume9
Issue number7
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Keywords

  • aortic valve stenosis
  • echocardiography
  • exercise
  • metabolic equivalent
  • outcome measures

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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