Predictors of Long-Term Healthy Arterial Aging

Coronary Artery Calcium Nondevelopment in the MESA Study

Seamus Whelton, Michael G. Silverman, John W. McEvoy, Matthew J. Budoff, Ron Blankstein, John Eng, Roger S Blumenthal, Moyses Szklo, Khurram Nasir, Michael Blaha

Research output: Contribution to journalArticle

Abstract

Objectives This study sought to determine the predictors of healthy arterial aging. Background Long-term nondevelopment of coronary artery calcification (persistent CAC = 0) is a marker of healthy arterial aging. The predictors of this phenotype are not known. Methods We analyzed 1,850 participants from MESA (Multi-Ethnic Study of Atherosclerosis) with baseline CAC = 0 who underwent a follow-up CAC scan at visit 5 (median 9.6 years after baseline). We examined the proportion with persistent CAC = 0 and calculated multivariable relative risks and area under the receiver operating characteristic curve for prediction of this healthy arterial aging phenotype. Results We found that 55% of participants (n = 1,000) had persistent CAC = 0, and these individuals were significantly more likely to be younger, female, and have fewer traditional risk factors (RF). Participants with an ASCVD (Atherosclerotic Cardiovascular Disease Risk Score) risk score

Original languageEnglish (US)
Pages (from-to)1393-1400
Number of pages8
JournalJACC: Cardiovascular Imaging
Volume8
Issue number12
DOIs
StatePublished - Dec 1 2015

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Atherosclerosis
Coronary Vessels
Calcium
Phenotype
ROC Curve
Cardiovascular Diseases

Keywords

  • arterial aging
  • cardiac computed tomography
  • cardiovascular disease
  • coronary artery calcium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Predictors of Long-Term Healthy Arterial Aging : Coronary Artery Calcium Nondevelopment in the MESA Study. / Whelton, Seamus; Silverman, Michael G.; McEvoy, John W.; Budoff, Matthew J.; Blankstein, Ron; Eng, John; Blumenthal, Roger S; Szklo, Moyses; Nasir, Khurram; Blaha, Michael.

In: JACC: Cardiovascular Imaging, Vol. 8, No. 12, 01.12.2015, p. 1393-1400.

Research output: Contribution to journalArticle

Whelton, Seamus ; Silverman, Michael G. ; McEvoy, John W. ; Budoff, Matthew J. ; Blankstein, Ron ; Eng, John ; Blumenthal, Roger S ; Szklo, Moyses ; Nasir, Khurram ; Blaha, Michael. / Predictors of Long-Term Healthy Arterial Aging : Coronary Artery Calcium Nondevelopment in the MESA Study. In: JACC: Cardiovascular Imaging. 2015 ; Vol. 8, No. 12. pp. 1393-1400.
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