Predictors of kidney biopsy complication among patients with systemic lupus erythematosus

Teresa Chen, M. M. Estrella, Derek M Fine

Research output: Contribution to journalArticle

Abstract

Kidney biopsy is essential for the diagnosis and management of lupus nephritis. The risk of bleeding complication, however, is not defined in the systemic lupus erythematosus population. A retrospective cohort study was conducted to determine predictors of major and minor complications among patients with systemic lupus erythematosus undergoing percutaneous ultrasound-guided kidney biopsy. Major complications included bleeding necessitating intervention, hypotension requiring vasopressors or higher level of care or death. Minor complications included moderate or large (≥ 4cm in largest diameter) perinephric hematoma, gross hematuria or voiding difficulties. All patients were observed for at least 23 h post-procedure. The overall incidence of bleeding was 10.5% (2.7% major, 7.8% minor). Adjusted logistic regression showed that for every 10,000 cells/mm3 decrease in platelet count, risk for major and any complication increased by 27% (odds ratio 1.27; 95% confidence intervals 1.06-1.51; p=0.01) and 8% (odds ratio 1.08; 95% confidence intervals 1.02-1.15; p=0.01), respectively. Patients with a platelet count

Original languageEnglish (US)
Pages (from-to)848-854
Number of pages7
JournalLupus
Volume21
Issue number8
DOIs
StatePublished - Jul 2012

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Systemic Lupus Erythematosus
Hemorrhage
Platelet Count
Kidney
Biopsy
Odds Ratio
Confidence Intervals
Lupus Nephritis
Hematuria
Hematoma
Hypotension
Cohort Studies
Retrospective Studies
Logistic Models
Incidence
Population

Keywords

  • bleeding complication
  • kidney biopsy
  • nephritis
  • Renal lupus
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Cite this

Predictors of kidney biopsy complication among patients with systemic lupus erythematosus. / Chen, Teresa; Estrella, M. M.; Fine, Derek M.

In: Lupus, Vol. 21, No. 8, 07.2012, p. 848-854.

Research output: Contribution to journalArticle

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