Predictors of HIV-associated nephropathy

Sana Waheed, Mohamed G. Atta

Research output: Contribution to journalReview articlepeer-review

Abstract

Renal disease accounts for significant morbidity and mortality in patients with HIV-1 infection. HIV-associated nephropathy (HIVAN) is an important cause of end stage renal disease in this population. Although multiple genetic, clinical, and laboratory characteristics such as Apolipoproetin-1 genetic polymorphism, high viral load, low CD-4 count, nephrotic range proteinuria, and increased renal echogenicity on ultrasound are predictive of HIVAN, kidney biopsy remains the gold standard to make the definitive diagnosis. Current treatment options for HIVAN include initiation of combined active antiretroviral therapy, blockade of the renin-angiotensin system, and steroids. In patients with progression of HIVAN, renal transplant should be pursued as long as their systemic HIV infection is controlled.

Original languageEnglish (US)
Pages (from-to)555-563
Number of pages9
JournalExpert Review of Anti-Infective Therapy
Volume12
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • APOL1
  • HIV
  • HIVAN
  • dialysis
  • kidney transplant

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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