Predictors of HIV-associated nephropathy

Sana Waheed, Mohamed Atta

Research output: Contribution to journalArticle

Abstract

Renal disease accounts for significant morbidity and mortality in patients with HIV-1 infection. HIV-associated nephropathy (HIVAN) is an important cause of end stage renal disease in this population. Although multiple genetic, clinical, and laboratory characteristics such as Apolipoproetin-1 genetic polymorphism, high viral load, low CD-4 count, nephrotic range proteinuria, and increased renal echogenicity on ultrasound are predictive of HIVAN, kidney biopsy remains the gold standard to make the definitive diagnosis. Current treatment options for HIVAN include initiation of combined active antiretroviral therapy, blockade of the renin-angiotensin system, and steroids. In patients with progression of HIVAN, renal transplant should be pursued as long as their systemic HIV infection is controlled.

Original languageEnglish (US)
Pages (from-to)555-563
Number of pages9
JournalExpert Review of Anti-Infective Therapy
Volume12
Issue number5
DOIs
StatePublished - 2014

Fingerprint

AIDS-Associated Nephropathy
Kidney
HIV Infections
Genetic Polymorphisms
Renin-Angiotensin System
Viral Load
Proteinuria
Chronic Kidney Failure
HIV-1
Steroids
Morbidity
Transplants
Biopsy
Mortality
Therapeutics
Population

Keywords

  • APOL1
  • dialysis
  • HIV
  • HIVAN
  • kidney transplant

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology
  • Medicine(all)

Cite this

Predictors of HIV-associated nephropathy. / Waheed, Sana; Atta, Mohamed.

In: Expert Review of Anti-Infective Therapy, Vol. 12, No. 5, 2014, p. 555-563.

Research output: Contribution to journalArticle

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