Abstract
Purpose To estimate 4-year change in serum total cholesterol levels in a population-based sample of older adults and identify independent predictors of cholesterol decline. Methods Prospective study of 2837 adults aged 65 years and older with serum cholesterol measured in 1992-1993 and 1996-1997. Results Mean serum cholesterol levels declined 6.3 mg/dl between the two examinations. Declines were greater in white (-7.3 mg/dl) than black (-1.4 mg/dl) participants and in those in good/excellent health (-0.9 mg/dl) vs. fair/poor health (-3.1 mg/dl; both p < 0.01). Factors associated with greater decline on multivariate analysis included age, male gender, and higher white cell count, albumin, and baseline cholesterol. Cholesterol levels declined 2.0 mg/dl per 6 year increment in baseline age and 6.8 mg/dl more in men than women after adjustment for other factors. C-reactive protein levels were unrelated to cholesterol change. Conclusion Declining cholesterol levels were associated with male gender, advanced age, weight loss, and white blood cell count but not with C-reactive protein levels. The role of declining cholesterol synthesis, due to as yet undefined age-related changes or to cytokine-mediated reductions related to illness, should be examined to help clarify the mechanisms of the sometimes marked declines in cholesterol levels observed at advanced ages.
Original language | English (US) |
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Pages (from-to) | 325-331 |
Number of pages | 7 |
Journal | Annals of epidemiology |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - May 2004 |
Keywords
- Aged
- CHS
- CVD
- Cardiovascular Health Study
- Cholesterol
- ECG
- Epidemiology
- Risk Factors
- cardiovascular disease
- electrocardiogram
ASJC Scopus subject areas
- Epidemiology