Predictors of delayed culture conversion in patients treated for multidrug-resistant tuberculosis in Pakistan

Fahad Qazi; U. Khan; S. Khowaja; M. Javaid; A. Ahmed; N. Salahuddin; H. Hussain; M. C. Becerra; J. E. Golub; A. J. Khan

doi:10.5588/ijtld.10.0679

Predictors of delayed culture conversion in patients treated for multidrug-resistant tuberculosis in Pakistan

Fahad Qazi, U. Khan, S. Khowaja, M. Javaid, A. Ahmed, N. Salahuddin, H. Hussain, M. C. Becerra, J. E. Golub, A. J. Khan

School of Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Culture conversion is an interim monitoring tool for treatment of multidrug-resistant tuberculosis (MDR-TB). We evaluated the time to and predictors of culture conversion in pulmonary MDR-TB patients enrolled in the community-based MDR-TB management program at the Indus Hospital in Karachi, Pakistan. Despite strict daily directly observed therapy, monthly food incentives and patient counseling, the median time to culture conversion was 196 days (range 32-471). The cumulative probabilities of culture conversion by 2, 4, 6 and 12 months were respectively 6%, 33%, 47%, and 73%. Smoking, high smear grade at baseline and previous use of second-line drugs delayed culture conversion.

Original language	English (US)
Pages (from-to)	1556-1559
Number of pages	4
Journal	International Journal of Tuberculosis and Lung Disease
Volume	15
Issue number	11
DOIs	https://doi.org/10.5588/ijtld.10.0679
State	Published - Nov 2011

Keywords

Culture conversion
Drug-resistant TB
MDR-TB
Pakistan

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

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10.5588/ijtld.10.0679

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title = "Predictors of delayed culture conversion in patients treated for multidrug-resistant tuberculosis in Pakistan",

abstract = "Culture conversion is an interim monitoring tool for treatment of multidrug-resistant tuberculosis (MDR-TB). We evaluated the time to and predictors of culture conversion in pulmonary MDR-TB patients enrolled in the community-based MDR-TB management program at the Indus Hospital in Karachi, Pakistan. Despite strict daily directly observed therapy, monthly food incentives and patient counseling, the median time to culture conversion was 196 days (range 32-471). The cumulative probabilities of culture conversion by 2, 4, 6 and 12 months were respectively 6%, 33%, 47%, and 73%. Smoking, high smear grade at baseline and previous use of second-line drugs delayed culture conversion.",

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AU - Khowaja, S.

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AU - Ahmed, A.

AU - Salahuddin, N.

AU - Hussain, H.

AU - Becerra, M. C.

AU - Golub, J. E.

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AB - Culture conversion is an interim monitoring tool for treatment of multidrug-resistant tuberculosis (MDR-TB). We evaluated the time to and predictors of culture conversion in pulmonary MDR-TB patients enrolled in the community-based MDR-TB management program at the Indus Hospital in Karachi, Pakistan. Despite strict daily directly observed therapy, monthly food incentives and patient counseling, the median time to culture conversion was 196 days (range 32-471). The cumulative probabilities of culture conversion by 2, 4, 6 and 12 months were respectively 6%, 33%, 47%, and 73%. Smoking, high smear grade at baseline and previous use of second-line drugs delayed culture conversion.

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Predictors of delayed culture conversion in patients treated for multidrug-resistant tuberculosis in Pakistan

Abstract

Keywords

ASJC Scopus subject areas

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