Predictors of delayed culture conversion in patients treated for multidrug-resistant tuberculosis in Pakistan

Fahad Qazi, U. Khan, S. Khowaja, M. Javaid, A. Ahmed, N. Salahuddin, H. Hussain, M. C. Becerra, J. E. Golub, A. J. Khan

Research output: Contribution to journalArticlepeer-review

Abstract

Culture conversion is an interim monitoring tool for treatment of multidrug-resistant tuberculosis (MDR-TB). We evaluated the time to and predictors of culture conversion in pulmonary MDR-TB patients enrolled in the community-based MDR-TB management program at the Indus Hospital in Karachi, Pakistan. Despite strict daily directly observed therapy, monthly food incentives and patient counseling, the median time to culture conversion was 196 days (range 32-471). The cumulative probabilities of culture conversion by 2, 4, 6 and 12 months were respectively 6%, 33%, 47%, and 73%. Smoking, high smear grade at baseline and previous use of second-line drugs delayed culture conversion.

Original languageEnglish (US)
Pages (from-to)1556-1559
Number of pages4
JournalInternational Journal of Tuberculosis and Lung Disease
Volume15
Issue number11
DOIs
StatePublished - Nov 2011

Keywords

  • Culture conversion
  • Drug-resistant TB
  • MDR-TB
  • Pakistan

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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